node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DXC78_00075 | DXC78_02545 | GCA_000420345_00366 | GCA_000420345_00717 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein. | 0.863 |
DXC78_00075 | fmt | GCA_000420345_00366 | GCA_000420345_00207 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.872 |
DXC78_00075 | folD | GCA_000420345_00366 | GCA_000420345_00889 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.481 |
DXC78_00075 | glyA | GCA_000420345_00366 | GCA_000420345_00896 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.883 |
DXC78_00075 | purN | GCA_000420345_00366 | GCA_000420345_01350 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.868 |
DXC78_02545 | DXC78_00075 | GCA_000420345_00717 | GCA_000420345_00366 | Unannotated protein. | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.863 |
DXC78_02545 | def | GCA_000420345_00717 | GCA_000420345_00919 | Unannotated protein. | Unannotated protein; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.843 |
DXC78_02545 | fmt | GCA_000420345_00717 | GCA_000420345_00207 | Unannotated protein. | Unannotated protein; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.881 |
DXC78_02545 | folD | GCA_000420345_00717 | GCA_000420345_00889 | Unannotated protein. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.761 |
DXC78_02545 | glyA | GCA_000420345_00717 | GCA_000420345_00896 | Unannotated protein. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
DXC78_02545 | metG | GCA_000420345_00717 | GCA_000420345_00518 | Unannotated protein. | Unannotated protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.892 |
DXC78_02545 | purN | GCA_000420345_00717 | GCA_000420345_01350 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.876 |
DXC78_02545 | rsmB | GCA_000420345_00717 | GCA_000420345_00004 | Unannotated protein. | Unannotated protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.415 |
DXC78_07855 | fmt | GCA_000420345_01347 | GCA_000420345_00207 | Unannotated protein. | Unannotated protein; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.909 |
DXC78_07855 | folD | GCA_000420345_01347 | GCA_000420345_00889 | Unannotated protein. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.748 |
DXC78_07855 | glyA | GCA_000420345_01347 | GCA_000420345_00896 | Unannotated protein. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
DXC78_07855 | metG | GCA_000420345_01347 | GCA_000420345_00518 | Unannotated protein. | Unannotated protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.846 |
DXC78_07855 | purN | GCA_000420345_01347 | GCA_000420345_01350 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
DXC78_07855 | rsmB | GCA_000420345_01347 | GCA_000420345_00004 | Unannotated protein. | Unannotated protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.528 |
def | DXC78_02545 | GCA_000420345_00919 | GCA_000420345_00717 | Unannotated protein; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Unannotated protein. | 0.843 |