SHJ67956.1 protein (Tepidibacter formicigenes)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SHJ67956.1

Diguanylate cyclase (GGDEF) domain-containing protein. (441 aa)

Predicted Functional Partners:

SHK41183.1

0.999

SHK16414.1

0.998

SHJ70758.1

0.997

SHJ97071.1

0.997

SHK52824.1

0.997

SHK52868.1

0.997

SHK58382.1

0.997

SHJ84215.1

0.996

SHJ90927.1

0.996

SHK00321.1

0.996

Your Current Organism:

Tepidibacter formicigenes

NCBI taxonomy Id: 1123349
Other names: T. formicigenes DSM 15518, Tepidibacter formicigenes DSM 15518

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHJ67956.1	SHJ70758.1	SAMN02744037_00585	SAMN02744037_00638	Diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.997
SHJ67956.1	SHJ84215.1	SAMN02744037_00585	SAMN02744037_00982	Diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.996
SHJ67956.1	SHJ90927.1	SAMN02744037_00585	SAMN02744037_01166	Diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.996
SHJ67956.1	SHJ97071.1	SAMN02744037_00585	SAMN02744037_01308	Diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.997
SHJ67956.1	SHK00321.1	SAMN02744037_00585	SAMN02744037_01401	Diguanylate cyclase (GGDEF) domain-containing protein.	Two-component system, chemotaxis family, response regulator CheV.	0.996
SHJ67956.1	SHK16414.1	SAMN02744037_00585	SAMN02744037_01767	Diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.998
SHJ67956.1	SHK41183.1	SAMN02744037_00585	SAMN02744037_02286	Diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.999
SHJ67956.1	SHK52824.1	SAMN02744037_00585	SAMN02744037_02531	Diguanylate cyclase (GGDEF) domain-containing protein.	Signal transduction histidine kinase.	0.997
SHJ67956.1	SHK52868.1	SAMN02744037_00585	SAMN02744037_02532	Diguanylate cyclase (GGDEF) domain-containing protein.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.997
SHJ67956.1	SHK58382.1	SAMN02744037_00585	SAMN02744037_02639	Diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.997
SHJ70758.1	SHJ67956.1	SAMN02744037_00638	SAMN02744037_00585	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.997
SHJ70758.1	SHJ84215.1	SAMN02744037_00638	SAMN02744037_00982	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.995
SHJ70758.1	SHJ90927.1	SAMN02744037_00638	SAMN02744037_01166	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.995
SHJ70758.1	SHJ97071.1	SAMN02744037_00638	SAMN02744037_01308	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.990
SHJ70758.1	SHK00321.1	SAMN02744037_00638	SAMN02744037_01401	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Two-component system, chemotaxis family, response regulator CheV.	0.995
SHJ70758.1	SHK16414.1	SAMN02744037_00638	SAMN02744037_01767	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.998
SHJ70758.1	SHK41183.1	SAMN02744037_00638	SAMN02744037_02286	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Diguanylate cyclase (GGDEF) domain-containing protein.	0.998
SHJ70758.1	SHK52824.1	SAMN02744037_00638	SAMN02744037_02531	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Signal transduction histidine kinase.	0.996
SHJ70758.1	SHK52868.1	SAMN02744037_00638	SAMN02744037_02532	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.995
SHJ70758.1	SHK58382.1	SAMN02744037_00638	SAMN02744037_02639	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.996

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.952

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042254

Ribosome biogenesis

6 of 16

1.9

2.99

1.32e-07

GO:0006364

rRNA processing

3 of 7

1.96

1.44

0.0014

GO:0042273

Ribosomal large subunit biogenesis

2 of 3

2.15

1.0

0.0137

GO:0042255

Ribosome assembly

2 of 4

2.03

0.95

0.0160

GO:0010467

Gene expression

8 of 224

0.88

0.8

0.00019

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

5 of 108

0.99

0.53

0.0400

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

3 of 3

2.33

2.28

4.41e-05

GO:1990904

Ribonucleoprotein complex

5 of 38

1.45

1.66

2.67e-05

GO:0031981

Nuclear lumen

3 of 16

1.6

1.34

0.0010

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 111

1.13

1.22

2.18e-05

GO:0005840

Ribosome

4 of 62

1.14

0.91

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1578

Mixed, incl. Preribosome, large subunit precursor, and FtsJ-like methyltransferase

7 of 10

2.17

4.95

9.48e-12

CL:1582

Ribosomal large subunit biogenesis, and rRNA processing

5 of 5

2.33

3.99

9.43e-09

CL:1428

Ribonucleoprotein, and Translation regulator activity

10 of 86

1.39

2.5

9.48e-12

CL:1427

Ribonucleoprotein, and Ribosome biogenesis

11 of 106

1.34

2.4

1.42e-12

CL:1443

Large ribosomal subunit, and Ribosomal protein

3 of 17

1.58

1.12

0.0037

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

4 of 61

1.15

0.71

0.0150

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

2 of 7

1.78

0.78

0.0307

GOCC:1990904

Ribonucleoprotein complex

3 of 34

1.27

0.67

0.0307

GOCC:0005634

Nucleus

3 of 41

1.19

0.64

0.0307

GOCC:0043229

Intracellular organelle

7 of 273

0.74

0.49

0.0147

GOCC:0043231

Intracellular membrane-bounded organelle

5 of 153

0.84

0.49

0.0307

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

2 of 4

2.03

0.9

0.0203

KW-0689

Ribosomal protein

4 of 58

1.17

0.69

0.0203

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