STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFP12672.1Acetolactate synthase, small subunit. (168 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
SFP12714.1
Acetolactate synthase, large subunit.
 
 0.998
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 0.994
SFO65223.1
Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase.
 
 0.992
SFO03722.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.990
SFP73021.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.990
SFO52627.1
Benzoylformate decarboxylase; Belongs to the TPP enzyme family.
 
 0.989
SFO52437.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.988
SFO65029.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
 
 0.986
SFQ00004.1
Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family.
 
 0.985
Your Current Organism:
Amycolatopsis rubida
NCBI taxonomy Id: 112413
Other names: A. rubida, Amycolatopsis rubida Huang et al. 2001, Amycolatopsis sp. 13.4, CIP 107102, DSM 44637, JCM 10871, NBRC 100041, NRRL B-24150, strain 13.4
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