node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFP43641.1 | SFQ64446.1 | SAMN05421854_105260 | SAMN05421854_117155 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.812 |
SFP43641.1 | SFQ68960.1 | SAMN05421854_105260 | SAMN05421854_11993 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | methionyl-tRNA formyltransferase. | 0.988 |
SFP43641.1 | fmt | SAMN05421854_105260 | SAMN05421854_105261 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.997 |
SFP43641.1 | folD | SAMN05421854_105260 | SAMN05421854_111216 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.868 |
SFP43641.1 | pheT | SAMN05421854_105260 | SAMN05421854_115172 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.971 |
SFP43641.1 | purN | SAMN05421854_105260 | SAMN05421854_111226 | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.492 |
SFQ64446.1 | SFP43641.1 | SAMN05421854_117155 | SAMN05421854_105260 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.812 |
SFQ64446.1 | SFQ68960.1 | SAMN05421854_117155 | SAMN05421854_11993 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase. | 0.918 |
SFQ64446.1 | fmt | SAMN05421854_117155 | SAMN05421854_105261 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.929 |
SFQ64446.1 | folD | SAMN05421854_117155 | SAMN05421854_111216 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.864 |
SFQ64446.1 | gcvT | SAMN05421854_117155 | SAMN05421854_1044 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.970 |
SFQ64446.1 | glyA | SAMN05421854_117155 | SAMN05421854_1011532 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
SFQ64446.1 | metG | SAMN05421854_117155 | SAMN05421854_109347 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.913 |
SFQ64446.1 | pheT | SAMN05421854_117155 | SAMN05421854_115172 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.788 |
SFQ64446.1 | purN | SAMN05421854_117155 | SAMN05421854_111226 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.921 |
SFQ64446.1 | thyX | SAMN05421854_117155 | SAMN05421854_103366 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.917 |
SFQ68960.1 | SFP43641.1 | SAMN05421854_11993 | SAMN05421854_105260 | methionyl-tRNA formyltransferase. | 16S rRNA (cytosine967-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.988 |
SFQ68960.1 | SFQ64446.1 | SAMN05421854_11993 | SAMN05421854_117155 | methionyl-tRNA formyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.918 |
SFQ68960.1 | fmt | SAMN05421854_11993 | SAMN05421854_105261 | methionyl-tRNA formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
SFQ68960.1 | folD | SAMN05421854_11993 | SAMN05421854_111216 | methionyl-tRNA formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |