GLIP_0096 protein (Aliiglaciecola lipolytica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

GLIP_0096

Major facilitator transporter. (400 aa)

Predicted Functional Partners:

GLIP_0095

0.566

narB

0.510

pheA

0.483

tyrA

0.453

ppsE

0.451

GLIP_1058

0.430

caiC

0.411

GLIP_3562

0.408

Your Current Organism:

Aliiglaciecola lipolytica

NCBI taxonomy Id: 1127673
Other names: A. lipolytica E3, Aliiglaciecola lipolytica E3, Glaciecola lipolytica E3, marine bacterium E3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLIP_0095	GLIP_0096	GLIP_0095	GLIP_0096	Hypothetical protein.	Major facilitator transporter.	0.566
GLIP_0096	GLIP_0095	GLIP_0096	GLIP_0095	Major facilitator transporter.	Hypothetical protein.	0.566
GLIP_0096	GLIP_1058	GLIP_0096	GLIP_1058	Major facilitator transporter.	Hypothetical protein.	0.430
GLIP_0096	GLIP_3562	GLIP_0096	GLIP_3562	Major facilitator transporter.	HlyD family secretion protein.	0.408
GLIP_0096	caiC	GLIP_0096	GLIP_1360	Major facilitator transporter.	crotonobetaine/carnitine-CoA ligase.	0.411
GLIP_0096	narB	GLIP_0096	GLIP_2402	Major facilitator transporter.	Nitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.	0.510
GLIP_0096	pheA	GLIP_0096	GLIP_2656	Major facilitator transporter.	Chorismate mutase.	0.483
GLIP_0096	ppsE	GLIP_0096	GLIP_1057	Major facilitator transporter.	Phenolpthiocerol synthesis type-I polyketide synthase E.	0.451
GLIP_0096	tyrA	GLIP_0096	GLIP_2655	Major facilitator transporter.	Chorismate mutase.	0.453
GLIP_1058	GLIP_0096	GLIP_1058	GLIP_0096	Hypothetical protein.	Major facilitator transporter.	0.430
GLIP_1058	caiC	GLIP_1058	GLIP_1360	Hypothetical protein.	crotonobetaine/carnitine-CoA ligase.	0.995
GLIP_1058	pheA	GLIP_1058	GLIP_2656	Hypothetical protein.	Chorismate mutase.	0.496
GLIP_1058	ppsE	GLIP_1058	GLIP_1057	Hypothetical protein.	Phenolpthiocerol synthesis type-I polyketide synthase E.	0.999
GLIP_1058	tyrA	GLIP_1058	GLIP_2655	Hypothetical protein.	Chorismate mutase.	0.576
GLIP_3562	GLIP_0096	GLIP_3562	GLIP_0096	HlyD family secretion protein.	Major facilitator transporter.	0.408
caiC	GLIP_0096	GLIP_1360	GLIP_0096	crotonobetaine/carnitine-CoA ligase.	Major facilitator transporter.	0.411
caiC	GLIP_1058	GLIP_1360	GLIP_1058	crotonobetaine/carnitine-CoA ligase.	Hypothetical protein.	0.995
caiC	ppsE	GLIP_1360	GLIP_1057	crotonobetaine/carnitine-CoA ligase.	Phenolpthiocerol synthesis type-I polyketide synthase E.	0.996
narB	GLIP_0096	GLIP_2402	GLIP_0096	Nitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.	Major facilitator transporter.	0.510
pheA	GLIP_0096	GLIP_2656	GLIP_0096	Chorismate mutase.	Major facilitator transporter.	0.483

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.815

expected number of edges:

14

PPI enrichment p-value:

4.8e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007259

Receptor signaling pathway via JAK-STAT

6 of 20

2.79

5.97

4.53e-12

GO:0019221

Cytokine-mediated signaling pathway

7 of 212

1.83

3.28

6.13e-09

GO:0007260

Tyrosine phosphorylation of STAT protein

3 of 4

3.19

2.98

3.96e-06

GO:0060397

Growth hormone receptor signaling pathway via JAK-STAT

3 of 5

3.09

2.9

5.43e-06

GO:0043434

Response to peptide hormone

5 of 167

1.79

2.19

1.06e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005131

Growth hormone receptor binding

3 of 5

3.09

2.7

1.24e-05

GO:0004715

Non-membrane spanning protein tyrosine kinase activity

3 of 47

2.12

1.49

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22435

Receptor signaling pathway via JAK-STAT, and 1-phosphatidylinositol-3-kinase regulator activity

8 of 27

2.78

8.91

3.45e-18

CL:22438

Receptor signaling pathway via JAK-STAT

7 of 14

3.01

8.69

4.13e-17

CL:22431

Cytokine-mediated signaling pathway, and 1-phosphatidylinositol-3-kinase regulator activity

10 of 101

2.31

7.98

2.66e-19

CL:22456

STAT protein, all-alpha domain, and Protein kinase

4 of 5

3.22

4.83

1.57e-09

CL:22440

Growth hormone receptor signaling pathway via JAK-STAT, and Suppressor of cytokine signalling

2 of 6

2.84

1.45

0.0023

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04217

Necroptosis

8 of 255

1.81

3.94

9.40e-12

map05168

Herpes simplex virus 1 infection

8 of 445

1.57

2.86

3.73e-10

map04625

C-type lectin receptor signaling pathway

5 of 194

1.72

2.43

1.08e-06

map04621

NOD-like receptor signaling pathway

7 of 445

1.51

2.4

2.44e-08

map04620

Toll-like receptor signaling pathway

3 of 120

1.71

1.41

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-909733

Interferon alpha/beta signaling

7 of 48

2.48

6.24

1.84e-13

MAP-877312

Regulation of IFNG signaling

5 of 10

3.01

5.9

1.16e-11

MAP-8854691

Interleukin-20 family signaling

6 of 33

2.57

5.76

4.46e-12

MAP-913531

Interferon Signaling

8 of 177

1.97

4.6

2.31e-12

MAP-877300

Interferon gamma signaling

5 of 48

2.33

4.04

7.36e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

5 of 121

1.93

2.76

7.79e-07

KW-0829

Tyrosine-protein kinase

3 of 81

1.88

1.42

0.0014

KW-0010

Activator

2 of 56

1.87

0.73

0.0408

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09294

Interferon-alpha/beta receptor, fibronectin type III

2 of 7

2.77

1.05

0.0125

PF02864

STAT protein, DNA binding domain

2 of 6

2.84

1.05

0.0125

PF01108

Tissue factor

2 of 6

2.84

1.05

0.0125

PF01017

STAT protein, all-alpha domain

2 of 8

2.71

1.05

0.0125

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

6 of 110

2.05

3.73

4.98e-09

SM00221

Protein kinase

3 of 3

3.31

3.44

5.89e-07

SM00295

Band 4.1 homologues

3 of 38

2.21

1.91

0.00021

SM00964

STAT protein, protein interaction domain

2 of 6

2.84

1.65

0.0010

SM01243

Interferon-regulatory factor 3

2 of 10

2.61

1.53

0.0016

(more ...)

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