GLIP_0381 protein (Aliiglaciecola lipolytica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GLIP_0381

Hypothetical protein. (691 aa)

Predicted Functional Partners:

GLIP_0388

0.997

GLIP_0385

0.996

GLIP_0389

0.993

GLIP_0382

0.992

GLIP_0383

0.990

GLIP_0380

0.989

GLIP_0390

0.987

GLIP_0386

0.897

GLIP_0050

0.890

GLIP_0392

0.886

Your Current Organism:

Aliiglaciecola lipolytica

NCBI taxonomy Id: 1127673
Other names: A. lipolytica E3, Aliiglaciecola lipolytica E3, Glaciecola lipolytica E3, marine bacterium E3

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GLIP_0050	GLIP_0380	Hypothetical protein.	Conserved hypothetical phage tail region protein subfamily.	0.849
GLIP_0050	GLIP_0381	Hypothetical protein.	Hypothetical protein.	0.890
GLIP_0050	GLIP_0382	Hypothetical protein.	Conserved hypothetical phage tail protein.	0.849
GLIP_0050	GLIP_0385	Hypothetical protein.	Hypothetical protein.	0.906
GLIP_0050	GLIP_0388	Hypothetical protein.	GPW/gp25 family protein.	0.948
GLIP_0050	GLIP_0389	Hypothetical protein.	Hypothetical protein.	0.947
GLIP_0380	GLIP_0050	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.849
GLIP_0380	GLIP_0381	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.989
GLIP_0380	GLIP_0382	Conserved hypothetical phage tail region protein subfamily.	Conserved hypothetical phage tail protein.	0.786
GLIP_0380	GLIP_0383	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.984
GLIP_0380	GLIP_0385	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.986
GLIP_0380	GLIP_0386	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.899
GLIP_0380	GLIP_0388	Conserved hypothetical phage tail region protein subfamily.	GPW/gp25 family protein.	0.990
GLIP_0380	GLIP_0389	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.990
GLIP_0380	GLIP_0390	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.879
GLIP_0380	GLIP_0392	Conserved hypothetical phage tail region protein subfamily.	Hypothetical protein.	0.877
GLIP_0381	GLIP_0050	Hypothetical protein.	Hypothetical protein.	0.890
GLIP_0381	GLIP_0380	Hypothetical protein.	Conserved hypothetical phage tail region protein subfamily.	0.989
GLIP_0381	GLIP_0382	Hypothetical protein.	Conserved hypothetical phage tail protein.	0.992
GLIP_0381	GLIP_0383	Hypothetical protein.	Hypothetical protein.	0.990

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00219

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009167

Purine ribonucleoside monophosphate metabolic process

5 of 11

1.93

2.86

4.00e-07

GO:0009150

Purine ribonucleotide metabolic process

8 of 49

1.49

2.33

2.79e-08

GO:0009165

Nucleotide biosynthetic process

8 of 60

1.4

2.12

2.79e-08

GO:0009132

Nucleoside diphosphate metabolic process

4 of 14

1.73

1.95

3.70e-05

GO:0046037

GMP metabolic process

3 of 5

2.05

1.92

0.00015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019205

Nucleobase-containing compound kinase activity

3 of 11

1.71

0.97

0.0112

GO:0004748

Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

2 of 2

2.27

0.93

0.0189

GO:0004385

Guanylate kinase activity

2 of 2

2.27

0.93

0.0189

GO:0106130

Purine phosphoribosyltransferase activity

2 of 4

1.97

0.91

0.0189

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

3 of 15

1.57

0.89

0.0144

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.98

0.0153

GO:0005737

Cytoplasm

10 of 713

0.42

0.31

0.0153

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:673

Mixed, incl. Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

7 of 21

1.8

3.37

1.38e-09

CL:676

Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

6 of 14

1.9

3.33

1.26e-08

CL:671

Mixed, incl. Nucleoside monophosphate metabolic process, and Pteridine-containing compound metabolic process

9 of 40

1.62

3.24

2.71e-11

CL:678

Purine nucleoside monophosphate biosynthetic process

2 of 6

1.8

0.69

0.0475

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 72

1.46

2.97

2.17e-14

map00240

Pyrimidine metabolism

3 of 43

1.12

0.55

0.0489

map01100

Metabolic pathways

11 of 614

0.53

0.46

8.76e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

3 of 19

1.47

1.05

0.0042

MAP-168256

Immune System

3 of 24

1.37

1.0

0.0042

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.82

0.0314

GOCC:0005622

Intracellular

10 of 759

0.39

0.28

0.0362

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0328

Glycosyltransferase

3 of 11

1.71

1.08

0.0063

KW-0660

Purine salvage

2 of 3

2.1

0.9

0.0205

KW-0808

Transferase

6 of 223

0.7

0.43

0.0264

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029057

Phosphoribosyltransferase-like

3 of 10

1.75

0.81

0.0266

IPR000836

Phosphoribosyltransferase domain

3 of 10

1.75

0.81

0.0266

IPR008145

Guanylate kinase/L-type calcium channel beta subunit

2 of 2

2.27

0.74

0.0438

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00072

Guanylate kinase homologues.

2 of 2

2.27

1.04

0.0116

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