STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
hisAKEGG: pru:PRU_0484 5.5e-73 hisA; 1-(5-phosphoribosyl)-5-((5'- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase K01814; Psort location: Cytoplasmic, score: 9.97. (241 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-ATP diphosphatase; KEGG: bth:BT_1377 4.6e-76 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; K11755 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisB
Histidinol-phosphatase; KEGG: pru:PRU_0455 4.1e-148 hisB; histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase K01089; Psort location: Cytoplasmic, score: 9.97; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 
 0.988
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 
 0.987
hisC
KEGG: pru:PRU_0388 6.1e-122 hisC; histidinol-phosphate transaminase K00817; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.955
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.896
EKY03516.1
Putative cell division ATP-binding protein FtsE; KEGG: cch:Cag_1444 3.0e-40 ATPase K09812; Psort location: CytoplasmicMembrane, score: 7.88.
       0.787
EKY03515.1
Putative aspartate kinase III; KEGG: pmz:HMPREF0659_A6515 3.5e-197 amino acid kinase family protein; K00928 aspartate kinase; Psort location: Cytoplasmic, score: 8.96; Belongs to the aspartokinase family.
  
  
 0.693
Your Current Organism:
Prevotella saccharolytica
NCBI taxonomy Id: 1127699
Other names: P. saccharolytica F0055, Prevotella saccharolytica F0055, Prevotella saccharolytica str. F0055, Prevotella saccharolytica strain F0055
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