| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKX99286.1 | EKX99651.1 | HMPREF9151_01769 | HMPREF9151_01597 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.996 |
| EKX99286.1 | guaB | HMPREF9151_01769 | HMPREF9151_02599 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.646 |
| EKX99286.1 | msrA | HMPREF9151_01769 | HMPREF9151_01253 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.715 |
| EKX99651.1 | EKX99286.1 | HMPREF9151_01597 | HMPREF9151_01769 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.996 |
| EKX99651.1 | guaB | HMPREF9151_01597 | HMPREF9151_02599 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.646 |
| EKX99651.1 | msrA | HMPREF9151_01597 | HMPREF9151_01253 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.715 |
| EKY02045.1 | EKY03623.1 | HMPREF9151_00937 | HMPREF9151_00265 | Cytochrome C biogenesis protein transmembrane region; KEGG: cpi:Cpin_7115 1.1e-147 protein-disulfide reductase; Psort location: CytoplasmicMembrane, score: 10.00. | Redoxin family protein; KEGG: cby:CLM_0322 1.3e-09 antioxidant, AhpC/TSA family; Psort location: CytoplasmicMembrane, score: 9.97. | 0.917 |
| EKY02045.1 | msrA | HMPREF9151_00937 | HMPREF9151_01253 | Cytochrome C biogenesis protein transmembrane region; KEGG: cpi:Cpin_7115 1.1e-147 protein-disulfide reductase; Psort location: CytoplasmicMembrane, score: 10.00. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.965 |
| EKY03623.1 | EKY02045.1 | HMPREF9151_00265 | HMPREF9151_00937 | Redoxin family protein; KEGG: cby:CLM_0322 1.3e-09 antioxidant, AhpC/TSA family; Psort location: CytoplasmicMembrane, score: 9.97. | Cytochrome C biogenesis protein transmembrane region; KEGG: cpi:Cpin_7115 1.1e-147 protein-disulfide reductase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.917 |
| EKY03623.1 | msrA | HMPREF9151_00265 | HMPREF9151_01253 | Redoxin family protein; KEGG: cby:CLM_0322 1.3e-09 antioxidant, AhpC/TSA family; Psort location: CytoplasmicMembrane, score: 9.97. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.994 |
| clpX | guaB | HMPREF9151_02327 | HMPREF9151_02599 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.491 |
| clpX | msrA | HMPREF9151_02327 | HMPREF9151_01253 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.689 |
| grpE | msrA | HMPREF9151_01755 | HMPREF9151_01253 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.712 |
| grpE | polA | HMPREF9151_01755 | HMPREF9151_02434 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.458 |
| guaB | EKX99286.1 | HMPREF9151_02599 | HMPREF9151_01769 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.646 |
| guaB | EKX99651.1 | HMPREF9151_02599 | HMPREF9151_01597 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.646 |
| guaB | clpX | HMPREF9151_02599 | HMPREF9151_02327 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.491 |
| guaB | msrA | HMPREF9151_02599 | HMPREF9151_01253 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.682 |
| guaB | polA | HMPREF9151_02599 | HMPREF9151_02434 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.407 |
| msrA | EKX99286.1 | HMPREF9151_01253 | HMPREF9151_01769 | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.715 |
