| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKX99728.1 | EKX99729.1 | HMPREF9151_01564 | HMPREF9151_01565 | Hypothetical protein. | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | 0.661 |
| EKX99728.1 | glyA | HMPREF9151_01564 | HMPREF9151_01568 | Hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.418 |
| EKX99728.1 | pyrB | HMPREF9151_01564 | HMPREF9151_01566 | Hypothetical protein. | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.467 |
| EKX99728.1 | pyrI | HMPREF9151_01564 | HMPREF9151_01567 | Hypothetical protein. | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.467 |
| EKX99729.1 | EKX99728.1 | HMPREF9151_01565 | HMPREF9151_01564 | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | Hypothetical protein. | 0.661 |
| EKX99729.1 | glyA | HMPREF9151_01565 | HMPREF9151_01568 | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.606 |
| EKX99729.1 | pyrB | HMPREF9151_01565 | HMPREF9151_01566 | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.651 |
| EKX99729.1 | pyrI | HMPREF9151_01565 | HMPREF9151_01567 | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.651 |
| glyA | EKX99728.1 | HMPREF9151_01568 | HMPREF9151_01564 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein. | 0.418 |
| glyA | EKX99729.1 | HMPREF9151_01568 | HMPREF9151_01565 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | 0.606 |
| glyA | pyrB | HMPREF9151_01568 | HMPREF9151_01566 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.804 |
| glyA | pyrI | HMPREF9151_01568 | HMPREF9151_01567 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.754 |
| pyrB | EKX99728.1 | HMPREF9151_01566 | HMPREF9151_01564 | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Hypothetical protein. | 0.467 |
| pyrB | EKX99729.1 | HMPREF9151_01566 | HMPREF9151_01565 | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | 0.651 |
| pyrB | glyA | HMPREF9151_01566 | HMPREF9151_01568 | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.804 |
| pyrB | pyrI | HMPREF9151_01566 | HMPREF9151_01567 | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.999 |
| pyrI | EKX99728.1 | HMPREF9151_01567 | HMPREF9151_01564 | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | Hypothetical protein. | 0.467 |
| pyrI | EKX99729.1 | HMPREF9151_01567 | HMPREF9151_01565 | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | Transglycosylase; KEGG: pru:PRU_0638 0. penicillin-binding protein 1A; K05366 penicillin-binding protein 1A; Psort location: CytoplasmicMembrane, score: 9.82. | 0.651 |
| pyrI | glyA | HMPREF9151_01567 | HMPREF9151_01568 | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.754 |
| pyrI | pyrB | HMPREF9151_01567 | HMPREF9151_01566 | Aspartate carbamoyltransferase regulatory chain, allosteric domain protein; Involved in allosteric regulation of aspartate carbamoyltransferase. | KEGG: pru:PRU_0637 4.7e-147 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |