Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (262 aa)    
Predicted Functional Partners:
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
    
 0.912
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.895
pyrH
UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.883
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 
 0.864
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
  
  0.863
cmk
Cytidylate kinase; KEGG: pru:PRU_1828 2.6e-91 cmk; cytidylate kinase K00945; Psort location: Cytoplasmic, score: 9.97.
    
 0.859
EKX98606.1
Adenylosuccinate lyase; KEGG: pmz:HMPREF0659_A6153 5.7e-197 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
    
 0.857
EKX98396.1
KEGG: pmz:HMPREF0659_A6356 1.6e-231 phosphoribulokinase/uridine kinase family protein; K00876 uridine kinase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.856
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
  0.854
pyrF
KEGG: pmz:HMPREF0659_A6727 4.6e-108 pyrF; orotidine 5'-phosphate decarboxylase K01591; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.849
Your Current Organism:
Prevotella saccharolytica
NCBI taxonomy Id: 1127699
Other names: P. saccharolytica F0055, Prevotella saccharolytica F0055, Prevotella saccharolytica str. F0055, Prevotella saccharolytica strain F0055
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