| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKX98784.1 | EKX99286.1 | HMPREF9151_01904 | HMPREF9151_01769 | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.904 |
| EKX98784.1 | EKX99507.1 | HMPREF9151_01904 | HMPREF9151_01704 | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | 0.829 |
| EKX98784.1 | EKX99651.1 | HMPREF9151_01904 | HMPREF9151_01597 | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.802 |
| EKX98784.1 | metK | HMPREF9151_01904 | HMPREF9151_01229 | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.853 |
| EKX99286.1 | EKX98784.1 | HMPREF9151_01769 | HMPREF9151_01904 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | 0.904 |
| EKX99286.1 | EKX99507.1 | HMPREF9151_01769 | HMPREF9151_01704 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | 0.829 |
| EKX99286.1 | EKX99651.1 | HMPREF9151_01769 | HMPREF9151_01597 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.996 |
| EKX99286.1 | metK | HMPREF9151_01769 | HMPREF9151_01229 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.945 |
| EKX99507.1 | EKX98784.1 | HMPREF9151_01704 | HMPREF9151_01904 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | 0.829 |
| EKX99507.1 | EKX99286.1 | HMPREF9151_01704 | HMPREF9151_01769 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.829 |
| EKX99507.1 | EKX99509.1 | HMPREF9151_01704 | HMPREF9151_01706 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | KEGG: pmz:HMPREF0659_A5803 4.0e-141 putative D-lactate dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.465 |
| EKX99507.1 | EKX99651.1 | HMPREF9151_01704 | HMPREF9151_01597 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 0.647 |
| EKX99507.1 | metK | HMPREF9151_01704 | HMPREF9151_01229 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.829 |
| EKX99507.1 | rsmA | HMPREF9151_01704 | HMPREF9151_01705 | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.825 |
| EKX99509.1 | EKX99507.1 | HMPREF9151_01706 | HMPREF9151_01704 | KEGG: pmz:HMPREF0659_A5803 4.0e-141 putative D-lactate dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | 0.465 |
| EKX99509.1 | rsmA | HMPREF9151_01706 | HMPREF9151_01705 | KEGG: pmz:HMPREF0659_A5803 4.0e-141 putative D-lactate dehydrogenase; K03778 D-lactate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.499 |
| EKX99651.1 | EKX98784.1 | HMPREF9151_01597 | HMPREF9151_01904 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | Cys/Met metabolism PLP-dependent enzyme; KEGG: pmz:HMPREF0659_A5993 1.7e-158 putative O-acetylhomoserine aminocarboxypropyltransferase; K01740 O-acetylhomoserine (thiol)-lyase; Psort location: Cytoplasmic, score: 9.97. | 0.802 |
| EKX99651.1 | EKX99286.1 | HMPREF9151_01597 | HMPREF9151_01769 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.996 |
| EKX99651.1 | EKX99507.1 | HMPREF9151_01597 | HMPREF9151_01704 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | GAF domain protein; KEGG: sti:Sthe_3242 0.00045 GAF sensor signal transduction histidine kinase. | 0.647 |
| EKX99651.1 | metK | HMPREF9151_01597 | HMPREF9151_01229 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: pdi:BDI_0415 7.1e-53 putative 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.787 |