| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKX98167.1 | EKY02854.1 | HMPREF9151_02046 | HMPREF9151_00661 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | Hypothetical protein. | 0.953 |
| EKX98167.1 | EKY03129.1 | HMPREF9151_02046 | HMPREF9151_00472 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.937 |
| EKX98167.1 | dnaJ | HMPREF9151_02046 | HMPREF9151_01754 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.704 |
| EKX98167.1 | dnaK | HMPREF9151_02046 | HMPREF9151_01125 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.929 |
| EKX98167.1 | gyrB | HMPREF9151_02046 | HMPREF9151_01832 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.835 |
| EKX98167.1 | truB | HMPREF9151_02046 | HMPREF9151_00834 | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.792 |
| EKX98916.1 | gyrB | HMPREF9151_01831 | HMPREF9151_01832 | Hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.596 |
| EKY02011.1 | gyrA | HMPREF9151_00902 | HMPREF9151_00778 | DNA gyrase/topoisomerase IV, A subunit; KEGG: pru:PRU_0008 0. topoisomerase GyrA/ParC subunit family protein; K02621 topoisomerase IV subunit A; Psort location: Cytoplasmic, score: 9.12. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.620 |
| EKY02011.1 | gyrB | HMPREF9151_00902 | HMPREF9151_01832 | DNA gyrase/topoisomerase IV, A subunit; KEGG: pru:PRU_0008 0. topoisomerase GyrA/ParC subunit family protein; K02621 topoisomerase IV subunit A; Psort location: Cytoplasmic, score: 9.12. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.932 |
| EKY02854.1 | EKX98167.1 | HMPREF9151_00661 | HMPREF9151_02046 | Hypothetical protein. | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | 0.953 |
| EKY02854.1 | EKY03129.1 | HMPREF9151_00661 | HMPREF9151_00472 | Hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.925 |
| EKY02854.1 | gyrB | HMPREF9151_00661 | HMPREF9151_01832 | Hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.748 |
| EKY03129.1 | EKX98167.1 | HMPREF9151_00472 | HMPREF9151_02046 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | 0.937 |
| EKY03129.1 | EKY02854.1 | HMPREF9151_00472 | HMPREF9151_00661 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein. | 0.925 |
| EKY03129.1 | gyrB | HMPREF9151_00472 | HMPREF9151_01832 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.498 |
| dnaJ | EKX98167.1 | HMPREF9151_01754 | HMPREF9151_02046 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | 0.704 |
| dnaJ | dnaK | HMPREF9151_01754 | HMPREF9151_01125 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
| dnaJ | gyrB | HMPREF9151_01754 | HMPREF9151_01832 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.642 |
| dnaK | EKX98167.1 | HMPREF9151_01125 | HMPREF9151_02046 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Helicase protein; KEGG: lsp:Bsph_0793 3.8e-17 ATP-dependent helicase YqhH; Psort location: Cytoplasmic, score: 8.96. | 0.929 |
| dnaK | dnaJ | HMPREF9151_01125 | HMPREF9151_01754 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.998 |
