STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (200 aa)    
Predicted Functional Partners:
EKX96960.1
Xanthine permease; KEGG: apb:SAR116_1372 3.0e-65 xanthine/uracil permease, putative K03458; Psort location: CytoplasmicMembrane, score: 10.00.
  
 0.948
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
 0.947
EKY02948.1
KEGG: pru:PRU_0310 4.6e-101 punA; purine nucleoside phosphorylase I, inosine and guanosine-specific K03783; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.924
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.897
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.896
EKX95888.1
KEGG: pru:PRU_2868 1.2e-68 hpt; hypoxanthine phosphoribosyltransferase K00760; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.860
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.849
EKX96555.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
 0.848
EKX95884.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.835
EKX97289.1
Ser/Thr phosphatase family protein.
     
 0.830
Your Current Organism:
Prevotella saccharolytica
NCBI taxonomy Id: 1127699
Other names: P. saccharolytica F0055, Prevotella saccharolytica F0055, Prevotella saccharolytica str. F0055, Prevotella saccharolytica strain F0055
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