AC579_7870 protein (Pseudocercospora musae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AC579_7870

Uncharacterized protein. (356 aa)

Predicted Functional Partners:

AC579_7627

0.954

AC579_1269

0.950

AC579_3313

0.937

AC579_9766

0.800

AC579_7881

0.741

AC579_10289

0.737

AC579_1312

0.724

AC579_7245

0.724

AC579_6702

0.724

AC579_8500

0.714

Your Current Organism:

Pseudocercospora musae

NCBI taxonomy Id: 113226
Other names: Mycosphaerella musicola, Mycosphaerella musicola R. Leach, P. musae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AC579_10289	AC579_1269	A0A139ICC9	A0A139II85	Uncharacterized protein.	Uncharacterized protein.	0.553
AC579_10289	AC579_3313	A0A139ICC9	A0A139I0U5	Uncharacterized protein.	Uncharacterized protein.	0.465
AC579_10289	AC579_7627	A0A139ICC9	A0A139ICB2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.840
AC579_10289	AC579_7870	A0A139ICC9	A0A139I2S7	Uncharacterized protein.	Uncharacterized protein.	0.737
AC579_10289	AC579_8500	A0A139ICC9	A0A139IFV4	Uncharacterized protein.	Uncharacterized protein.	0.562
AC579_10289	AC579_9766	A0A139ICC9	A0A139IFY0	Uncharacterized protein.	Uncharacterized protein.	0.737
AC579_1269	AC579_10289	A0A139II85	A0A139ICC9	Uncharacterized protein.	Uncharacterized protein.	0.553
AC579_1269	AC579_1312	A0A139II85	A0A139I693	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.671
AC579_1269	AC579_3313	A0A139II85	A0A139I0U5	Uncharacterized protein.	Uncharacterized protein.	0.837
AC579_1269	AC579_6702	A0A139II85	A0A139II37	Uncharacterized protein.	Uncharacterized protein.	0.671
AC579_1269	AC579_7245	A0A139II85	A0A139IEY4	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.671
AC579_1269	AC579_7627	A0A139II85	A0A139ICB2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.849
AC579_1269	AC579_7870	A0A139II85	A0A139I2S7	Uncharacterized protein.	Uncharacterized protein.	0.950
AC579_1269	AC579_7881	A0A139II85	A0A139I6P1	Uncharacterized protein.	Phosphodiesterase.	0.919
AC579_1269	AC579_8500	A0A139II85	A0A139IFV4	Uncharacterized protein.	Uncharacterized protein.	0.681
AC579_1269	AC579_9766	A0A139II85	A0A139IFY0	Uncharacterized protein.	Uncharacterized protein.	0.875
AC579_1312	AC579_1269	A0A139I693	A0A139II85	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.671
AC579_1312	AC579_7870	A0A139I693	A0A139I2S7	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.724
AC579_1312	AC579_9766	A0A139I693	A0A139IFY0	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.724
AC579_3313	AC579_10289	A0A139I0U5	A0A139ICC9	Uncharacterized protein.	Uncharacterized protein.	0.465

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.794

expected number of edges:

11

PPI enrichment p-value:

9.54e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006730

One-carbon metabolic process

4 of 9

2.06

2.24

2.92e-05

GO:0000096

Sulfur amino acid metabolic process

4 of 15

1.84

1.92

7.83e-05

GO:0009066

Aspartate family amino acid metabolic process

5 of 31

1.62

1.86

2.92e-05

GO:0009067

Aspartate family amino acid biosynthetic process

4 of 20

1.71

1.69

0.00018

GO:0006555

Methionine metabolic process

3 of 7

2.04

1.65

0.00058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

2.41

1.79

0.00046

GO:0008172

S-methyltransferase activity

2 of 3

2.23

0.94

0.0180

GO:0019842

Vitamin binding

3 of 36

1.33

0.65

0.0389

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1144

Cysteine and methionine metabolism, and Homoserine kinase activity

10 of 21

2.09

6.38

3.43e-17

CL:1146

Cysteine and methionine metabolism, and Homoserine kinase activity

8 of 15

2.14

5.46

1.68e-13

CL:1147

Adenosylhomocysteinase-like, and Threonine biosynthetic process

7 of 10

2.26

5.36

2.37e-12

CL:1150

Homocysteine-binding domain, and Adenosylhomocysteinase-like

5 of 5

2.41

4.12

7.08e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ttr00270

Cysteine and methionine metabolism

9 of 32

1.86

4.62

5.66e-14

ttr00450

Selenocompound metabolism

3 of 10

1.89

1.76

0.00023

ttr00260

Glycine, serine and threonine metabolism

4 of 26

1.6

1.71

7.83e-05

ttr01230

Biosynthesis of amino acids

6 of 104

1.17

1.25

3.82e-05

ttr01110

Biosynthesis of secondary metabolites

7 of 253

0.85

0.76

0.00023

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

3 of 7

2.04

1.55

0.00092

KW-0486

Methionine biosynthesis

2 of 4

2.11

0.93

0.0183

KW-0520

NAD

3 of 38

1.31

0.71

0.0256

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02574

Homocysteine S-methyltransferase

2 of 2

2.41

0.79

0.0365

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

2.41

1.61

0.0010

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

2.41

1.61

0.0010

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

1.61

0.0010

IPR000043

Adenosylhomocysteinase-like

3 of 3

2.41

1.61

0.0010

IPR036589

Homocysteine-binding domain superfamily

2 of 2

2.41

0.93

0.0196

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

2.14

9.34e-05

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