AC579_1188 protein (Pseudocercospora musae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AC579_1188

Uncharacterized protein. (373 aa)

Predicted Functional Partners:

AC579_6219

0.799

AC579_818

0.699

AC579_5638

0.688

AC579_10152

0.659

AC579_2005

0.626

AC579_232

0.620

AC579_3313

0.607

AC579_4929

0.585

AC579_7627

0.566

AC579_8875

0.540

Your Current Organism:

Pseudocercospora musae

NCBI taxonomy Id: 113226
Other names: Mycosphaerella musicola, Mycosphaerella musicola R. Leach, P. musae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AC579_10152	AC579_1188	A0A139IS63	A0A139I6R2	Uncharacterized protein.	Uncharacterized protein.	0.659
AC579_10152	AC579_232	A0A139IS63	A0A139H6Z8	Uncharacterized protein.	Uncharacterized protein.	0.562
AC579_10152	AC579_4929	A0A139IS63	A0A139I266	Uncharacterized protein.	Uncharacterized protein.	0.497
AC579_10152	AC579_5638	A0A139IS63	A0A139IEM7	Uncharacterized protein.	Uncharacterized protein.	0.820
AC579_10152	AC579_6219	A0A139IS63	A0A139HTG4	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.601
AC579_10152	AC579_818	A0A139IS63	A0A139IC24	Uncharacterized protein.	Uncharacterized protein.	0.965
AC579_1188	AC579_10152	A0A139I6R2	A0A139IS63	Uncharacterized protein.	Uncharacterized protein.	0.659
AC579_1188	AC579_2005	A0A139I6R2	A0A139IQV7	Uncharacterized protein.	Uncharacterized protein.	0.626
AC579_1188	AC579_232	A0A139I6R2	A0A139H6Z8	Uncharacterized protein.	Uncharacterized protein.	0.620
AC579_1188	AC579_3313	A0A139I6R2	A0A139I0U5	Uncharacterized protein.	Uncharacterized protein.	0.607
AC579_1188	AC579_4929	A0A139I6R2	A0A139I266	Uncharacterized protein.	Uncharacterized protein.	0.585
AC579_1188	AC579_5638	A0A139I6R2	A0A139IEM7	Uncharacterized protein.	Uncharacterized protein.	0.688
AC579_1188	AC579_6219	A0A139I6R2	A0A139HTG4	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.799
AC579_1188	AC579_7627	A0A139I6R2	A0A139ICB2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.566
AC579_1188	AC579_818	A0A139I6R2	A0A139IC24	Uncharacterized protein.	Uncharacterized protein.	0.699
AC579_1188	AC579_8875	A0A139I6R2	A0A139I504	Uncharacterized protein.	Flavin_Reduct domain-containing protein.	0.540
AC579_2005	AC579_1188	A0A139IQV7	A0A139I6R2	Uncharacterized protein.	Uncharacterized protein.	0.626
AC579_2005	AC579_4929	A0A139IQV7	A0A139I266	Uncharacterized protein.	Uncharacterized protein.	0.735
AC579_2005	AC579_5638	A0A139IQV7	A0A139IEM7	Uncharacterized protein.	Uncharacterized protein.	0.988
AC579_2005	AC579_6219	A0A139IQV7	A0A139HTG4	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.858

expected number of edges:

16

PPI enrichment p-value:

1.71e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051287

NAD binding

3 of 16

1.94

1.83

0.0018

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

3 of 20

1.84

1.77

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1086

Mixed, incl. D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Aminotransferase class-V, pyridoxal-phosphate binding site

4 of 7

2.42

4.51

2.90e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00680

Methane metabolism

2 of 19

1.69

0.98

0.0355

map01120

Microbial metabolism in diverse environments

4 of 141

1.12

0.95

0.0035

map00260

Glycine, serine and threonine metabolism

2 of 27

1.53

0.87

0.0455

map00270

Cysteine and methionine metabolism

2 of 31

1.47

0.84

0.0455

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 3

2.66

3.49

1.99e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain

3 of 3

2.66

3.16

5.85e-05

IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site

2 of 2

2.66

1.6

0.0081

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain

2 of 2

2.66

1.6

0.0081

IPR036291

NAD(P)-binding domain superfamily

3 of 34

1.61

1.28

0.0081

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