AC579_5129 protein (Pseudocercospora musae) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

AC579_5129

HUN domain-containing protein. (652 aa)

Predicted Functional Partners:

AC579_1228

0.942

AC579_8464

0.509

AC579_1896

0.506

AC579_152

0.498

AC579_1187

0.470

AC579_6174

0.470

AC579_7077

0.451

AC579_1350

0.451

AC579_5638

0.433

AC579_8794

0.405

Your Current Organism:

Pseudocercospora musae

NCBI taxonomy Id: 113226
Other names: Mycosphaerella musicola, Mycosphaerella musicola R. Leach, P. musae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AC579_1187	AC579_152	A0A139I6W0	A0A139HMA6	2Fe-2S ferredoxin-type domain-containing protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.779
AC579_1187	AC579_5129	A0A139I6W0	A0A139IPH1	2Fe-2S ferredoxin-type domain-containing protein.	HUN domain-containing protein.	0.470
AC579_1228	AC579_5129	A0A139I5R2	A0A139IPH1	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	HUN domain-containing protein.	0.942
AC579_1350	AC579_5129	A0A139IPN2	A0A139IPH1	FSH1 domain-containing protein.	HUN domain-containing protein.	0.451
AC579_1350	AC579_7077	A0A139IPN2	A0A139I5K4	FSH1 domain-containing protein.	FSH1 domain-containing protein.	0.774
AC579_1350	AC579_8464	A0A139IPN2	A0A139I2H2	FSH1 domain-containing protein.	Carrier domain-containing protein.	0.414
AC579_152	AC579_1187	A0A139HMA6	A0A139I6W0	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	2Fe-2S ferredoxin-type domain-containing protein.	0.779
AC579_152	AC579_1896	A0A139HMA6	A0A139I285	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.495
AC579_152	AC579_5129	A0A139HMA6	A0A139IPH1	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	HUN domain-containing protein.	0.498
AC579_152	AC579_6174	A0A139HMA6	A0A139IS21	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Uncharacterized protein.	0.779
AC579_152	AC579_8464	A0A139HMA6	A0A139I2H2	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Carrier domain-containing protein.	0.572
AC579_1896	AC579_152	A0A139I285	A0A139HMA6	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.495
AC579_1896	AC579_5129	A0A139I285	A0A139IPH1	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	HUN domain-containing protein.	0.506
AC579_1896	AC579_8464	A0A139I285	A0A139I2H2	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Carrier domain-containing protein.	0.848
AC579_5129	AC579_1187	A0A139IPH1	A0A139I6W0	HUN domain-containing protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.470
AC579_5129	AC579_1228	A0A139IPH1	A0A139I5R2	HUN domain-containing protein.	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	0.942
AC579_5129	AC579_1350	A0A139IPH1	A0A139IPN2	HUN domain-containing protein.	FSH1 domain-containing protein.	0.451
AC579_5129	AC579_152	A0A139IPH1	A0A139HMA6	HUN domain-containing protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.498
AC579_5129	AC579_1896	A0A139IPH1	A0A139I285	HUN domain-containing protein.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.506
AC579_5129	AC579_5638	A0A139IPH1	A0A139IEM7	HUN domain-containing protein.	Uncharacterized protein.	0.433

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

0.00172

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 221

1.47

1.6

6.34e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.04

1.32

0.0041

GO:0022900

Electron transport chain

3 of 61

1.73

0.93

0.0137

GO:0006633

Fatty acid biosynthetic process

3 of 70

1.67

0.89

0.0164

GO:0045454

Cell redox homeostasis

2 of 14

2.2

0.85

0.0272

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 4

2.74

1.06

0.0121

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 3

2.86

1.06

0.0121

GO:0000062

fatty-acyl-CoA binding

2 of 8

2.44

0.95

0.0181

GO:0016491

Oxidoreductase activity

7 of 1709

0.65

0.38

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 7

2.5

1.06

0.0115

GO:0005739

Mitochondrion

8 of 1098

0.9

0.78

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10559

Beta-ketoacyl synthase, C-terminal domain, and Lipoate metabolic process

2 of 5

2.64

0.82

0.0329

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

2 of 12

2.26

0.78

0.0365

CL:13747

Mixed, incl. Sulfide oxidation to sulfate, and Sulfate assimilation

2 of 27

1.91

0.76

0.0370

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

3 of 71

1.67

0.73

0.0365

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

3 of 137

1.38

0.69

0.0328

map00071

Fatty acid degradation

3 of 133

1.39

0.69

0.0328

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.86

1.36

0.0035

MAP-6783984

Glycine degradation

2 of 6

2.56

1.32

0.0039

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 53

1.79

1.21

0.0035

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.14

0.97

0.0152

MAP-8978868

Fatty acid metabolism

5 of 345

1.2

0.91

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005967

Mitochondrial pyruvate dehydrogenase complex

2 of 5

2.64

1.07

0.0112

GOCC:0005759

Mitochondrial matrix

4 of 165

1.43

0.88

0.0112

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.57

0.0146

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

3 of 9

2.56

2.43

2.99e-05

KW-0520

NAD

2 of 46

1.68

0.71

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 21

2.2

1.54

0.0012

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.22

0.0060

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 10

2.34

0.96

0.0175

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001753

Enoyl-CoA hydratase/isomerase

3 of 22

2.18

1.29

0.0037

IPR029045

ClpP/crotonase-like domain superfamily

3 of 34

1.99

1.15

0.0062

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

2 of 5

2.64

1.08

0.0110

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.08

0.0110

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

2 of 4

2.74

1.08

0.0110

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