STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)    
Predicted Functional Partners:
ligA
NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
    
 0.972
SHJG_2642
MutT-like protein.
 
     0.915
SHJG_6417
DNA ligase.
   
 0.889
ku
Ku70/Ku80 protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.887
SHJG_8689
Putative Ku70/Ku80 protein.
 
  
 0.877
SHJG_3117
DNA polymerase beta.
 
 0.874
SHJG_7611
Hypothetical protein.
   
 0.839
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.800
SHJG_2640
Reductase.
     
 0.787
SHJG_2643
Putative aldehyde dehydrogenase.
       0.782
Your Current Organism:
Streptomyces hygroscopicus jinggangensis
NCBI taxonomy Id: 1133850
Other names: S. hygroscopicus subsp. jinggangensis 5008, Streptomyces hygroscopicus subsp. jinggangensis 5008, Streptomyces hygroscopicus subsp. jinggangensis str. 5008, Streptomyces hygroscopicus subsp. jinggangensis strain 5008
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