sfswap protein (Scleropages formosus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

sfswap

Splicing factor, suppressor of white-apricot-like. (965 aa)

Predicted Functional Partners:

srrm1

0.679

sf3a3

0.626

sf3a2

0.572

Z043_122511

0.549

Z043_114016

0.455

srrm4

0.442

Dpagt1

0.439

Z043_119204

0.437

srek1

0.414

Ccnl1

0.411

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccnl1	sfswap	ENSSFOP00015044864	ENSSFOP00015001036	Cyclin-L1-like; Belongs to the cyclin family.	Splicing factor, suppressor of white-apricot-like.	0.411
Dpagt1	sfswap	ENSSFOP00015051949	ENSSFOP00015001036	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase-like.	Splicing factor, suppressor of white-apricot-like.	0.439
Z043_114016	sfswap	ENSSFOP00015027421	ENSSFOP00015001036	Protein cramped-like.	Splicing factor, suppressor of white-apricot-like.	0.455
Z043_119204	sf3a2	ENSSFOP00015012468	ENSSFOP00015064636	Calcium homeostasis endoplasmic reticulum protein-like.	Splicing factor 3A subunit 2-like.	0.899
Z043_119204	sf3a3	ENSSFOP00015012468	ENSSFOP00015009224	Calcium homeostasis endoplasmic reticulum protein-like.	Splicing factor 3A subunit 3-like.	0.741
Z043_119204	sfswap	ENSSFOP00015012468	ENSSFOP00015001036	Calcium homeostasis endoplasmic reticulum protein-like.	Splicing factor, suppressor of white-apricot-like.	0.437
Z043_122511	sfswap	ENSSFOP00015014532	ENSSFOP00015001036	Uncharacterized protein.	Splicing factor, suppressor of white-apricot-like.	0.549
sf3a2	Z043_119204	ENSSFOP00015064636	ENSSFOP00015012468	Splicing factor 3A subunit 2-like.	Calcium homeostasis endoplasmic reticulum protein-like.	0.899
sf3a2	sf3a3	ENSSFOP00015064636	ENSSFOP00015009224	Splicing factor 3A subunit 2-like.	Splicing factor 3A subunit 3-like.	0.999
sf3a2	sfswap	ENSSFOP00015064636	ENSSFOP00015001036	Splicing factor 3A subunit 2-like.	Splicing factor, suppressor of white-apricot-like.	0.572
sf3a2	srrm1	ENSSFOP00015064636	ENSSFOP00015037720	Splicing factor 3A subunit 2-like.	PWI domain-containing protein.	0.835
sf3a3	Z043_119204	ENSSFOP00015009224	ENSSFOP00015012468	Splicing factor 3A subunit 3-like.	Calcium homeostasis endoplasmic reticulum protein-like.	0.741
sf3a3	sf3a2	ENSSFOP00015009224	ENSSFOP00015064636	Splicing factor 3A subunit 3-like.	Splicing factor 3A subunit 2-like.	0.999
sf3a3	sfswap	ENSSFOP00015009224	ENSSFOP00015001036	Splicing factor 3A subunit 3-like.	Splicing factor, suppressor of white-apricot-like.	0.626
sf3a3	srrm1	ENSSFOP00015009224	ENSSFOP00015037720	Splicing factor 3A subunit 3-like.	PWI domain-containing protein.	0.776
sfswap	Ccnl1	ENSSFOP00015001036	ENSSFOP00015044864	Splicing factor, suppressor of white-apricot-like.	Cyclin-L1-like; Belongs to the cyclin family.	0.411
sfswap	Dpagt1	ENSSFOP00015001036	ENSSFOP00015051949	Splicing factor, suppressor of white-apricot-like.	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase-like.	0.439
sfswap	Z043_114016	ENSSFOP00015001036	ENSSFOP00015027421	Splicing factor, suppressor of white-apricot-like.	Protein cramped-like.	0.455
sfswap	Z043_119204	ENSSFOP00015001036	ENSSFOP00015012468	Splicing factor, suppressor of white-apricot-like.	Calcium homeostasis endoplasmic reticulum protein-like.	0.437
sfswap	Z043_122511	ENSSFOP00015001036	ENSSFOP00015014532	Splicing factor, suppressor of white-apricot-like.	Uncharacterized protein.	0.549

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.733

expected number of edges:

12

PPI enrichment p-value:

1.22e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014059

Regulation of dopamine secretion

6 of 23

2.72

5.75

1.01e-11

GO:0017158

Regulation of calcium ion-dependent exocytosis

6 of 29

2.62

5.65

1.01e-11

GO:0017156

Calcium-ion regulated exocytosis

6 of 33

2.57

5.53

1.39e-11

GO:0048791

Calcium ion-regulated exocytosis of neurotransmitter

5 of 16

2.8

5.24

1.35e-10

GO:0048488

Synaptic vesicle endocytosis

6 of 43

2.45

5.2

3.71e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019905

Syntaxin binding

9 of 77

2.38

7.71

8.51e-18

GO:0000149

SNARE binding

10 of 124

2.21

7.36

1.21e-18

GO:0001786

Phosphatidylserine binding

6 of 40

2.48

5.34

2.15e-11

GO:0005544

Calcium-dependent phospholipid binding

6 of 59

2.32

4.75

1.42e-10

GO:0030276

Clathrin binding

6 of 68

2.25

4.59

2.12e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030667

Secretory granule membrane

6 of 33

2.57

6.02

1.20e-12

GO:0030672

Synaptic vesicle membrane

8 of 103

2.2

6.0

1.45e-14

GO:0031045

Dense core granule

5 of 18

2.75

5.5

3.47e-11

GO:0070382

Exocytic vesicle

9 of 192

1.98

5.27

1.08e-14

GO:0099503

Secretory vesicle

10 of 329

1.79

4.51

7.60e-15

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26022

Neurotransmitter secretion, and Synaptobrevin

8 of 34

2.68

8.16

5.74e-17

CL:25998

Mixed, incl. Neurotransmitter secretion, and Neurotransmitter loading into synaptic vesicle

9 of 84

2.34

7.28

5.74e-17

CL:26024

Synaptic vesicle exocytosis, and Sec1 family

5 of 27

2.58

4.78

5.70e-10

CL:26028

Other interleukin signaling, and Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

4 of 14

2.76

4.06

2.61e-08

CL:26046

Mixed, incl. Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex, and SNARE complex assembly

2 of 5

2.91

1.63

0.0011

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

4 of 68

2.08

2.54

6.32e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

11 of 168

2.12

7.47

1.04e-20

MAP-8856828

Clathrin-mediated endocytosis

11 of 231

1.99

6.41

1.57e-19

MAP-181429

Serotonin Neurotransmitter Release Cycle

4 of 26

2.5

3.42

2.86e-07

MAP-181430

Norepinephrine Neurotransmitter Release Cycle

4 of 29

2.45

3.35

3.56e-07

MAP-264642

Acetylcholine Neurotransmitter Release Cycle

4 of 34

2.38

3.22

5.49e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042584

Chromaffin granule membrane

5 of 9

3.05

6.02

7.50e-12

GOCC:0099503

Secretory vesicle

10 of 224

1.96

5.59

2.13e-16

GOCC:0030659

Cytoplasmic vesicle membrane

9 of 255

1.86

4.51

1.58e-13

GOCC:0030141

Secretory granule

6 of 141

1.94

3.55

4.12e-09

GOCC:0098588

Bounding membrane of organelle

9 of 878

1.32

2.06

1.64e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0677

Repeat

6 of 1292

0.98

0.72

0.0047

KW-1133

Transmembrane helix

9 of 6095

0.48

0.3

0.0451

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00957

Synaptobrevin

4 of 12

2.83

3.72

1.30e-07

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00239

Protein kinase C conserved region 2 (CalB)

7 of 165

1.94

3.88

3.50e-10

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