Z043_114472 protein (Scleropages formosus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

Z043_114472

Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)

Predicted Functional Partners:

LOC108931159

0.757

cldn11

0.733

cldn5

0.711

LOC114910673

0.711

ENSSFOP00015002786

0.708

ENSSFOP00015075471

0.708

CLDN10

0.702

Z043_125791

0.702

LOC108937251

0.689

LOC108921529

0.688

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN10	ENSSFOP00015002786	ENSSFOP00015005237	ENSSFOP00015002786	Claudin-10-like.	Claudin-16-like.	0.711
CLDN10	ENSSFOP00015075471	ENSSFOP00015005237	ENSSFOP00015075471	Claudin-10-like.	Claudin-16-like.	0.711
CLDN10	LOC108921529	ENSSFOP00015005237	ENSSFOP00015019735	Claudin-10-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
CLDN10	LOC108931159	ENSSFOP00015005237	ENSSFOP00015023604	Claudin-10-like.	Tight junction protein ZO-1-like; Belongs to the MAGUK family.	0.708
CLDN10	LOC108937251	ENSSFOP00015005237	ENSSFOP00015068944	Claudin-10-like.	Claudin-1-like.	0.664
CLDN10	LOC114910673	ENSSFOP00015005237	ENSSFOP00015065861	Claudin-10-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.676
CLDN10	Z043_114472	ENSSFOP00015005237	ENSSFOP00015015423	Claudin-10-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.702
CLDN10	Z043_125791	ENSSFOP00015005237	ENSSFOP00015005577	Claudin-10-like.	Claudin-10-like.	0.656
CLDN10	cldn11	ENSSFOP00015005237	ENSSFOP00015013625	Claudin-10-like.	Claudin-11-like.	0.686
CLDN10	cldn5	ENSSFOP00015005237	ENSSFOP00015044293	Claudin-10-like.	Claudin-5-like.	0.676
ENSSFOP00015002786	CLDN10	ENSSFOP00015002786	ENSSFOP00015005237	Claudin-16-like.	Claudin-10-like.	0.711
ENSSFOP00015002786	ENSSFOP00015075471	ENSSFOP00015002786	ENSSFOP00015075471	Claudin-16-like.	Claudin-16-like.	0.654
ENSSFOP00015002786	LOC108921529	ENSSFOP00015002786	ENSSFOP00015019735	Claudin-16-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.748
ENSSFOP00015002786	LOC108931159	ENSSFOP00015002786	ENSSFOP00015023604	Claudin-16-like.	Tight junction protein ZO-1-like; Belongs to the MAGUK family.	0.756
ENSSFOP00015002786	LOC108937251	ENSSFOP00015002786	ENSSFOP00015068944	Claudin-16-like.	Claudin-1-like.	0.748
ENSSFOP00015002786	LOC114910673	ENSSFOP00015002786	ENSSFOP00015065861	Claudin-16-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.779
ENSSFOP00015002786	Z043_114472	ENSSFOP00015002786	ENSSFOP00015015423	Claudin-16-like.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.708
ENSSFOP00015002786	Z043_125791	ENSSFOP00015002786	ENSSFOP00015005577	Claudin-16-like.	Claudin-10-like.	0.711
ENSSFOP00015002786	cldn11	ENSSFOP00015002786	ENSSFOP00015013625	Claudin-16-like.	Claudin-11-like.	0.687
ENSSFOP00015002786	cldn5	ENSSFOP00015002786	ENSSFOP00015044293	Claudin-16-like.	Claudin-5-like.	0.779

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.891

expected number of edges:

12

PPI enrichment p-value:

1.62e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

5 of 176

1.33

1.22

0.00050

GO:0009987

Cellular process

11 of 3593

0.36

0.28

0.0221

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

7 of 32

2.22

5.2

3.57e-12

GO:0042626

ATPase-coupled transmembrane transporter activity

8 of 58

2.02

4.83

1.28e-12

GO:0005524

ATP binding

8 of 550

1.04

1.15

4.65e-06

GO:0036094

Small molecule binding

9 of 819

0.92

0.96

4.10e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

9 of 2221

0.49

0.31

0.0384

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8633

Serralysin-like metalloprotease, C-terminal, and Peptidase C39, bacteriocin processing

4 of 26

2.06

2.08

6.89e-05

CL:8637

RTX calcium-binding nonapeptide repeat (4 copies), and Peptidase C39 family

3 of 18

2.1

1.67

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

7 of 214

1.39

1.94

3.37e-07

map03070

Bacterial secretion system

3 of 51

1.65

1.2

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

2 of 13

2.06

1.33

0.0028

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

2 of 53

1.45

0.8

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030256

Type I protein secretion system complex

5 of 6

2.8

5.16

1.94e-10

GOCC:0032991

Protein-containing complex

7 of 856

0.79

0.58

0.0043

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

7 of 326

1.21

1.39

1.01e-05

KW-0596

Phosphopantetheine

2 of 19

1.9

0.85

0.0240

KW-0472

Membrane

7 of 1240

0.63

0.4

0.0240

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00664

ABC transporter transmembrane region

6 of 14

2.51

5.31

3.01e-11

PF03412

Peptidase C39 family

3 of 4

2.75

2.52

2.33e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039421

Type 1 protein exporter

6 of 15

2.48

5.03

1.03e-10

IPR036640

ABC transporter type 1, transmembrane domain superfamily

6 of 15

2.48

5.03

1.03e-10

IPR011527

ABC transporter type 1, transmembrane domain

6 of 15

2.48

5.03

1.03e-10

IPR017871

ABC transporter-like, conserved site

7 of 50

2.02

4.25

1.03e-10

IPR003439

ABC transporter-like, ATP-binding domain

7 of 58

1.96

4.04

1.57e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

6 of 117

1.59

2.27

6.09e-07

SM00100

Cyclic nucleotide-monophosphate binding domain

2 of 14

2.03

0.98

0.0142

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