UBL3 protein (Scleropages formosus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

UBL3

Ubiquitin-like domain-containing protein. (144 aa)

Predicted Functional Partners:

psmd6

0.860

katnb1

0.844

psmd12

0.838

Z043_102951

0.836

psmd2

0.835

psmd13

0.831

Psmb4

0.812

psmd3

0.779

LOC108941572

0.779

Z043_108448

0.779

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108941572	Psmb4	ENSSFOP00015047687	ENSSFOP00015007672	26S proteasome non-ATPase regulatory subunit 3-like.	Uncharacterized protein.	0.974
LOC108941572	UBL3	ENSSFOP00015047687	ENSSFOP00015044602	26S proteasome non-ATPase regulatory subunit 3-like.	Ubiquitin-like domain-containing protein.	0.779
LOC108941572	Z043_102951	ENSSFOP00015047687	ENSSFOP00015054306	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 4-like.	0.987
LOC108941572	Z043_108448	ENSSFOP00015047687	ENSSFOP00015054597	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 11A-like.	0.965
LOC108941572	psmd12	ENSSFOP00015047687	ENSSFOP00015059590	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 12-like.	0.990
LOC108941572	psmd13	ENSSFOP00015047687	ENSSFOP00015033000	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 13-like.	0.990
LOC108941572	psmd2	ENSSFOP00015047687	ENSSFOP00015056088	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.987
LOC108941572	psmd3	ENSSFOP00015047687	ENSSFOP00015008191	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 3-like.	0.900
LOC108941572	psmd6	ENSSFOP00015047687	ENSSFOP00015038868	26S proteasome non-ATPase regulatory subunit 3-like.	26S proteasome non-ATPase regulatory subunit 6-like.	0.990
Psmb4	LOC108941572	ENSSFOP00015007672	ENSSFOP00015047687	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 3-like.	0.974
Psmb4	UBL3	ENSSFOP00015007672	ENSSFOP00015044602	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.812
Psmb4	Z043_102951	ENSSFOP00015007672	ENSSFOP00015054306	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 4-like.	0.999
Psmb4	Z043_108448	ENSSFOP00015007672	ENSSFOP00015054597	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 11A-like.	0.984
Psmb4	psmd12	ENSSFOP00015007672	ENSSFOP00015059590	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 12-like.	0.997
Psmb4	psmd13	ENSSFOP00015007672	ENSSFOP00015033000	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 13-like.	0.995
Psmb4	psmd2	ENSSFOP00015007672	ENSSFOP00015056088	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.991
Psmb4	psmd3	ENSSFOP00015007672	ENSSFOP00015008191	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 3-like.	0.974
Psmb4	psmd6	ENSSFOP00015007672	ENSSFOP00015038868	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 6-like.	0.997
UBL3	LOC108941572	ENSSFOP00015044602	ENSSFOP00015047687	Ubiquitin-like domain-containing protein.	26S proteasome non-ATPase regulatory subunit 3-like.	0.779
UBL3	Psmb4	ENSSFOP00015044602	ENSSFOP00015007672	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.812

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Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

3 of 5

2.97

2.2

9.87e-05

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

3 of 11

2.63

1.9

0.00032

GO:0002027

Regulation of heart rate

3 of 43

2.04

1.19

0.0053

GO:0060047

Heart contraction

3 of 55

1.93

1.06

0.0089

GO:0098974

Postsynaptic actin cytoskeleton organization

2 of 10

2.5

0.88

0.0248

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008307

Structural constituent of muscle

4 of 15

2.62

3.21

9.46e-07

GO:0050998

Nitric-oxide synthase binding

3 of 10

2.67

2.24

7.55e-05

GO:0005198

Structural molecule activity

5 of 572

1.14

0.71

0.0147

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

8 of 17

2.87

9.27

1.20e-18

GO:0042383

Sarcolemma

8 of 81

2.19

5.89

2.58e-14

GO:0030175

Filopodium

3 of 81

1.76

1.21

0.0034

GO:0002102

Podosome

2 of 15

2.32

1.18

0.0066

GO:0033017

Sarcoplasmic reticulum membrane

2 of 22

2.15

1.03

0.0120

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19754

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF-hand

9 of 35

2.61

8.94

3.78e-19

CL:19755

Dystrophin-associated glycoprotein complex, and EF-hand

7 of 24

2.66

7.07

1.16e-14

CL:19782

Dystrophin-associated glycoprotein complex

5 of 5

3.2

6.2

4.16e-12

CL:19757

Dystrophin-associated glycoprotein complex, and EF-hand

6 of 19

2.7

6.17

1.16e-12

CL:19805

Nitric oxide synthase, oxygenase domain, and Regulation of peptidyl-cysteine S-nitrosylation

2 of 6

2.72

1.31

0.0042

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 238

1.3

0.97

0.0037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042383

Sarcolemma

7 of 55

2.3

5.42

2.73e-12

GOCC:0016010

Dystrophin-associated glycoprotein complex

2 of 15

2.32

0.98

0.0154

GOCC:0005886

Plasma membrane

8 of 1914

0.82

0.65

0.0018

GOCC:0016020

Membrane

10 of 3789

0.62

0.48

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04790

Sarcoglycan complex subunit protein

3 of 5

2.97

2.56

2.18e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00736

Dystroglycan-type cadherin-like domains.

2 of 3

3.02

1.42

0.0027

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