LOC108935817 protein (Scleropages formosus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

LOC108935817

Aquaporin-8-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (273 aa)

Predicted Functional Partners:

aqp11

0.719

aqp9

0.634

Z043_124608

0.633

aqp10

0.629

LOC108924962

0.628

LOC108937482

0.628

LOC108918196

0.620

aqp4

0.601

AQP4

0.600

LOC108918195

0.580

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP4	LOC108918196	ENSSFOP00015011883	ENSSFOP00015021309	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.529
AQP4	LOC108924962	ENSSFOP00015011883	ENSSFOP00015031285	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-3-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.560
AQP4	LOC108935817	ENSSFOP00015011883	ENSSFOP00015050094	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-8-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.600
AQP4	LOC108937482	ENSSFOP00015011883	ENSSFOP00015033817	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.514
AQP4	Z043_124608	ENSSFOP00015011883	ENSSFOP00015024935	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 3-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.558
AQP4	aqp10	ENSSFOP00015011883	ENSSFOP00015033250	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.627
AQP4	aqp11	ENSSFOP00015011883	ENSSFOP00015059667	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.625
AQP4	aqp9	ENSSFOP00015011883	ENSSFOP00015072631	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaglyceroporin-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.545
LOC108918195	LOC108918196	ENSSFOP00015021146	ENSSFOP00015021309	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.551
LOC108918195	LOC108924962	ENSSFOP00015021146	ENSSFOP00015031285	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-3-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.560
LOC108918195	LOC108935817	ENSSFOP00015021146	ENSSFOP00015050094	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-8-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.580
LOC108918195	LOC108937482	ENSSFOP00015021146	ENSSFOP00015033817	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.528
LOC108918195	Z043_124608	ENSSFOP00015021146	ENSSFOP00015024935	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 3-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.555
LOC108918195	aqp10	ENSSFOP00015021146	ENSSFOP00015033250	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.563
LOC108918195	aqp11	ENSSFOP00015021146	ENSSFOP00015059667	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.625
LOC108918195	aqp9	ENSSFOP00015021146	ENSSFOP00015072631	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaglyceroporin-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.556
LOC108918196	AQP4	ENSSFOP00015021309	ENSSFOP00015011883	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.529
LOC108918196	LOC108918195	ENSSFOP00015021309	ENSSFOP00015021146	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.551
LOC108918196	LOC108924962	ENSSFOP00015021309	ENSSFOP00015031285	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-3-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.603
LOC108918196	LOC108935817	ENSSFOP00015021309	ENSSFOP00015050094	Lens fiber major intrinsic protein-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-8-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.620

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.906

expected number of edges:

14

PPI enrichment p-value:

1.47e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

7 of 46

1.78

3.23

3.43e-09

GO:0009055

Electron transfer activity

8 of 79

1.6

2.82

2.36e-09

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

2 of 10

1.9

0.71

0.0445

GO:0046872

Metal ion binding

8 of 631

0.7

0.52

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 9

2.12

1.74

0.00041

GO:0070069

Cytochrome complex

2 of 3

2.42

1.27

0.0046

GO:0098803

Respiratory chain complex

2 of 6

2.12

1.16

0.0063

GO:0016020

Membrane

10 of 1353

0.47

0.36

0.0046

GO:0016021

Integral component of membrane

8 of 980

0.51

0.35

0.0182

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3160

Mixed, incl. Oxidative phosphorylation, and Immunoglobulin-like fold

9 of 45

1.9

4.74

7.78e-14

CL:3158

Mixed, incl. Oxidative phosphorylation, and Cytochrome c-like domain superfamily

10 of 59

1.83

4.69

5.27e-15

CL:3162

Mixed, incl. Oxidoreduction-driven active transmembrane transporter activity, and Cytochrome c-like domain

6 of 27

1.94

3.46

8.43e-09

CL:3229

Respiratory chain, and 4Fe-4S dicluster domain

3 of 5

2.38

2.16

8.02e-05

CL:3167

Oxidoreduction-driven active transmembrane transporter activity, and 4Fe-4S binding domain

2 of 7

2.05

0.9

0.0199

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

5 of 46

1.63

2.02

1.01e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

8 of 29

2.04

4.98

6.26e-13

GOCC:0070069

Cytochrome complex

3 of 5

2.38

2.09

0.00011

GOCC:0098803

Respiratory chain complex

3 of 12

1.99

1.63

0.00057

GOCC:0045278

Plasma membrane respiratory chain complex IV

2 of 2

2.6

1.4

0.0028

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

8 of 36

1.94

4.54

2.06e-12

KW-0679

Respiratory chain

3 of 5

2.38

2.32

3.86e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13442

Cytochrome C oxidase, cbb3-type, subunit III

3 of 6

2.3

1.68

0.00067

PF00034

Cytochrome c

3 of 12

1.99

1.4

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009056

Cytochrome c-like domain

6 of 21

2.05

3.47

2.54e-08

IPR036909

Cytochrome c-like domain superfamily

6 of 24

1.99

3.39

2.54e-08

IPR008168

Cytochrome c, class IC

2 of 3

2.42

0.8

0.0346

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