Brd2 protein (Scleropages formosus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Brd2

Bromodomain-containing protein 2-like. (801 aa)

Predicted Functional Partners:

Taf7l

0.735

LOC108938788

0.661

E2f1

0.649

cdk9

0.636

jmjd6

0.625

LOC108934435

0.620

yeats4

0.564

crbn

0.560

LOC108934463

0.553

Z043_105726

0.553

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd2	E2f1	ENSSFOP00015062286	ENSSFOP00015022896	Bromodomain-containing protein 2-like.	Transcription factor E2F1-like.	0.649
Brd2	LOC108934435	ENSSFOP00015062286	ENSSFOP00015006614	Bromodomain-containing protein 2-like.	Uncharacterized protein.	0.620
Brd2	LOC108934463	ENSSFOP00015062286	ENSSFOP00015020679	Bromodomain-containing protein 2-like.	Uncharacterized protein.	0.553
Brd2	LOC108938788	ENSSFOP00015062286	ENSSFOP00015025613	Bromodomain-containing protein 2-like.	DNA methyltransferase 1-associated protein 1-like.	0.661
Brd2	Taf7l	ENSSFOP00015062286	ENSSFOP00015059204	Bromodomain-containing protein 2-like.	Transcription initiation factor TFIID subunit 7-like.	0.735
Brd2	Z043_105726	ENSSFOP00015062286	ENSSFOP00015031549	Bromodomain-containing protein 2-like.	Histone-lysine N-methyltransferase NSD3-like.	0.553
Brd2	cdk9	ENSSFOP00015062286	ENSSFOP00015022593	Bromodomain-containing protein 2-like.	Cyclin-dependent kinase 9-like; Belongs to the protein kinase superfamily.	0.636
Brd2	crbn	ENSSFOP00015062286	ENSSFOP00015030824	Bromodomain-containing protein 2-like.	Protein cereblon-like.	0.560
Brd2	jmjd6	ENSSFOP00015062286	ENSSFOP00015000813	Bromodomain-containing protein 2-like.	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-like.	0.625
Brd2	yeats4	ENSSFOP00015062286	ENSSFOP00015079236	Bromodomain-containing protein 2-like.	YEATS domain-containing protein 4-like.	0.564
E2f1	Brd2	ENSSFOP00015022896	ENSSFOP00015062286	Transcription factor E2F1-like.	Bromodomain-containing protein 2-like.	0.649
LOC108934435	Brd2	ENSSFOP00015006614	ENSSFOP00015062286	Uncharacterized protein.	Bromodomain-containing protein 2-like.	0.620
LOC108934435	Taf7l	ENSSFOP00015006614	ENSSFOP00015059204	Uncharacterized protein.	Transcription initiation factor TFIID subunit 7-like.	0.999
LOC108934435	yeats4	ENSSFOP00015006614	ENSSFOP00015079236	Uncharacterized protein.	YEATS domain-containing protein 4-like.	0.628
LOC108934463	Brd2	ENSSFOP00015020679	ENSSFOP00015062286	Uncharacterized protein.	Bromodomain-containing protein 2-like.	0.553
LOC108938788	Brd2	ENSSFOP00015025613	ENSSFOP00015062286	DNA methyltransferase 1-associated protein 1-like.	Bromodomain-containing protein 2-like.	0.661
LOC108938788	yeats4	ENSSFOP00015025613	ENSSFOP00015079236	DNA methyltransferase 1-associated protein 1-like.	YEATS domain-containing protein 4-like.	0.980
Taf7l	Brd2	ENSSFOP00015059204	ENSSFOP00015062286	Transcription initiation factor TFIID subunit 7-like.	Bromodomain-containing protein 2-like.	0.735
Taf7l	LOC108934435	ENSSFOP00015059204	ENSSFOP00015006614	Transcription initiation factor TFIID subunit 7-like.	Uncharacterized protein.	0.999
Taf7l	yeats4	ENSSFOP00015059204	ENSSFOP00015079236	Transcription initiation factor TFIID subunit 7-like.	YEATS domain-containing protein 4-like.	0.561

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

5 of 40

1.47

1.42

0.00029

GO:0006281

DNA repair

5 of 41

1.46

1.41

0.00029

GO:0009432

SOS response

3 of 11

1.81

1.34

0.0018

GO:0006259

DNA metabolic process

8 of 141

1.13

1.23

1.51e-05

GO:0006261

DNA-templated DNA replication

3 of 15

1.67

1.19

0.0032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

7 of 71

1.37

1.73

2.97e-06

GO:0003684

Damaged DNA binding

3 of 6

2.07

1.62

0.00069

GO:0003887

DNA-directed DNA polymerase activity

3 of 9

1.89

1.42

0.0014

GO:0008094

ATP-dependent activity, acting on DNA

3 of 21

1.53

0.97

0.0081

GO:0003677

DNA binding

8 of 207

0.96

0.93

7.60e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:511

DNA damage sensor activity, and DNA-directed DNA polymerase activity

5 of 7

2.23

3.43

1.04e-07

CL:509

DNA-directed DNA polymerase activity, and SOS response

6 of 17

1.92

3.14

6.03e-08

CL:916

Glycerolipid biosynthetic process, and Regulation of response to stimulus

2 of 6

1.89

0.72

0.0425

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

3 of 12

1.77

1.25

0.0027

map03430

Mismatch repair

3 of 20

1.55

1.05

0.0052

map03440

Homologous recombination

3 of 30

1.37

0.87

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

4 of 23

1.61

1.55

0.00027

KW-0227

DNA damage

4 of 23

1.61

1.55

0.00027

KW-0235

DNA replication

3 of 13

1.73

1.36

0.0014

KW-0238

DNA-binding

7 of 113

1.16

1.28

1.98e-05

KW-0239

DNA-directed DNA polymerase

2 of 5

1.97

0.99

0.0126

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About