notch1 protein (Scleropages formosus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

notch1

Neurogenic locus notch protein-like. (2530 aa)

Predicted Functional Partners:

rbpj

0.996

DLL4

0.983

Dll1

0.981

dll3

0.981

Rbpjl

0.961

maml1

0.954

adam17

0.954

numbl

0.949

jag1

0.943

LOC108933797

0.943

Your Current Organism:

Scleropages formosus

NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	Dll1	ENSSFOP00015026218	ENSSFOP00015048518	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
DLL4	Rbpjl	ENSSFOP00015026218	ENSSFOP00015006573	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein-like.	0.543
DLL4	dll3	ENSSFOP00015026218	ENSSFOP00015067993	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
DLL4	maml1	ENSSFOP00015026218	ENSSFOP00015058161	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind-like protein 1-like.	0.502
DLL4	notch1	ENSSFOP00015026218	ENSSFOP00015067493	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch protein-like.	0.983
DLL4	rbpj	ENSSFOP00015026218	ENSSFOP00015044671	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like.	0.668
Dll1	DLL4	ENSSFOP00015048518	ENSSFOP00015026218	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
Dll1	Rbpjl	ENSSFOP00015048518	ENSSFOP00015006573	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein-like.	0.543
Dll1	dll3	ENSSFOP00015048518	ENSSFOP00015067993	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
Dll1	notch1	ENSSFOP00015048518	ENSSFOP00015067493	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch protein-like.	0.981
Dll1	rbpj	ENSSFOP00015048518	ENSSFOP00015044671	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like.	0.642
LOC108933797	Rbpjl	ENSSFOP00015061320	ENSSFOP00015006573	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein-like.	0.543
LOC108933797	jag1	ENSSFOP00015061320	ENSSFOP00015015179	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC108933797	maml1	ENSSFOP00015061320	ENSSFOP00015058161	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind-like protein 1-like.	0.487
LOC108933797	notch1	ENSSFOP00015061320	ENSSFOP00015067493	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch protein-like.	0.943
LOC108933797	rbpj	ENSSFOP00015061320	ENSSFOP00015044671	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like.	0.667
Rbpjl	DLL4	ENSSFOP00015006573	ENSSFOP00015026218	Recombining binding protein suppressor of hairless-like protein-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.543
Rbpjl	Dll1	ENSSFOP00015006573	ENSSFOP00015048518	Recombining binding protein suppressor of hairless-like protein-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.543
Rbpjl	LOC108933797	ENSSFOP00015006573	ENSSFOP00015061320	Recombining binding protein suppressor of hairless-like protein-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.543
Rbpjl	dll3	ENSSFOP00015006573	ENSSFOP00015067993	Recombining binding protein suppressor of hairless-like protein-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.543

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051123

RNA polymerase II preinitiation complex assembly

8 of 18

2.92

9.32

1.35e-18

GO:0006367

Transcription initiation from RNA polymerase II promoter

9 of 34

2.7

9.28

2.13e-19

GO:0006352

DNA-templated transcription, initiation

10 of 81

2.36

8.24

2.13e-19

GO:0042789

mRNA transcription by RNA polymerase II

8 of 41

2.56

7.65

2.33e-16

GO:0060261

Positive regulation of transcription initiation from RNA polymerase II promoter

8 of 46

2.51

7.42

4.48e-16

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016251

RNA polymerase II general transcription initiation factor activity

5 of 25

2.57

4.39

3.55e-09

GO:0140296

General transcription initiation factor binding

5 of 54

2.24

3.54

6.18e-08

GO:0017025

TBP-class protein binding

4 of 28

2.43

3.15

8.77e-07

GO:0046982

Protein heterodimerization activity

8 of 334

1.65

2.94

2.81e-09

GO:0008134

Transcription factor binding

8 of 636

1.37

1.99

8.87e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

10 of 29

2.81

11.72

3.14e-24

GO:0033276

Transcription factor TFTC complex

6 of 14

2.9

7.14

3.19e-14

GO:0070461

SAGA-type complex

7 of 37

2.55

6.95

8.57e-15

GO:0000124

SAGA complex

4 of 23

2.51

3.73

6.89e-08

GO:0071339

MLL1 complex

4 of 34

2.34

3.35

2.61e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4168

RNA polymerase II preinitiation complex assembly

9 of 10

3.23

12.24

1.25e-23

CL:4125

Transcription factor TFIID complex, and Transcription factor TFIIH holo complex

10 of 34

2.74

11.2

1.63e-23

CL:4172

SLIK (SAGA-like) complex, and Lateral mesoderm formation

5 of 5

3.27

6.35

2.44e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03022

Basal transcription factors

9 of 34

2.7

9.97

5.56e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

9 of 49

2.54

8.68

5.40e-19

MAP-75953

RNA Polymerase II Transcription Initiation

9 of 49

2.54

8.68

5.40e-19

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

9 of 49

2.54

8.68

5.40e-19

MAP-73776

RNA Polymerase II Promoter Escape

9 of 49

2.54

8.68

5.40e-19

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 101

2.22

6.9

4.69e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016591

RNA polymerase II, holoenzyme

10 of 64

2.47

9.27

4.03e-21

GOCC:0070461

SAGA-type complex

7 of 34

2.59

7.03

7.63e-15

GOCC:0071339

MLL1 complex

4 of 26

2.46

3.55

1.37e-07

GOCC:0005654

Nucleoplasm

11 of 696

1.47

3.04

1.99e-14

GOCC:1990234

Transferase complex

11 of 858

1.38

2.6

1.71e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

4 of 59

2.1

2.46

1.07e-05

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