STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tp53bp1Tumor suppressor p53-binding protein 1-like. (1892 aa)    
Predicted Functional Partners:
topbp1
DNA topoisomerase 2-binding protein 1-like.
    
 
 0.991
Z043_115886
Uncharacterized protein.
    
 0.981
Atm
Non-specific serine/threonine protein kinase.
    
 0.977
xrcc6
X-ray repair cross-complementing protein 5-like.
    
 0.966
rnf168
E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]
    
 0.957
chek1
Serine/threonine-protein kinase Chk1-like; Belongs to the protein kinase superfamily.
    
 
 0.956
atr
Serine/threonine-protein kinase ATR-like; Belongs to the PI3/PI4-kinase family.
    
 
 0.953
mdc1
Mediator of DNA damage checkpoint protein 1-like.
    
 0.952
Paxip1
PAX-interacting protein 1 isoform X1.
    
 0.952
brca1
Breast cancer type 1 susceptibility protein-like.
    
 0.944
Your Current Organism:
Scleropages formosus
NCBI taxonomy Id: 113540
Other names: Asian arowana, Asian bonytongue, Osteoglossum formosum, S. formosus, golden arowana, golden dragon fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.