STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCHydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (504 aa)    
Predicted Functional Partners:
SDT71141.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.999
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.993
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.988
SDT71145.1
Thiamine-phosphate pyrophosphorylase.
 
 
 0.974
SDT71154.1
Sulfur carrier protein ThiS.
 
  
 0.969
purM
Phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.912
SDT69982.1
FO synthase subunit 1 /FO synthase subunit 2.
  
  
 0.861
mqnC
De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
  
  
 0.861
SDT72767.1
Aminodeoxyfutalosine synthase.
  
  
 0.861
SDT71587.1
Adenylyltransferase and sulfurtransferase.
  
  
 0.776
Your Current Organism:
Actinoplanes derwentensis
NCBI taxonomy Id: 113562
Other names: A. derwentensis, ATCC 49798, DSM 43941, IFO 14935, JCM 7556, NBRC 14935, NCIB 12875, NCIB:12875, NCIMB 12875, NRRL B-16692, strain LA 107
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