node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEJ88411.1 | CEJ88412.1 | HYPGJ_31797 | HYPGJ_31798 | tRNA synthetase class II (G H P and S). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
CEJ88411.1 | CEJ89069.1 | HYPGJ_31797 | HYPGJ_40119 | tRNA synthetase class II (G H P and S). | Aminotransferase class I and II. | 0.712 |
CEJ88411.1 | hisA | HYPGJ_31797 | HYPGJ_10225 | tRNA synthetase class II (G H P and S). | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.903 |
CEJ88411.1 | hisB | HYPGJ_31797 | HYPGJ_10219 | tRNA synthetase class II (G H P and S). | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.900 |
CEJ88411.1 | hisD | HYPGJ_31797 | HYPGJ_31632 | tRNA synthetase class II (G H P and S). | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.912 |
CEJ88411.1 | hisE | HYPGJ_31797 | HYPGJ_10148 | tRNA synthetase class II (G H P and S). | Phosphoribosyl-ATP pyrophosphatase. | 0.975 |
CEJ88411.1 | hisF | HYPGJ_31797 | HYPGJ_10229 | tRNA synthetase class II (G H P and S). | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.953 |
CEJ88411.1 | hisH | HYPGJ_31797 | HYPGJ_10221 | tRNA synthetase class II (G H P and S). | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.880 |
CEJ88411.1 | hisI | HYPGJ_31797 | HYPGJ_20579 | tRNA synthetase class II (G H P and S). | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.947 |
CEJ88412.1 | CEJ88411.1 | HYPGJ_31798 | HYPGJ_31797 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | tRNA synthetase class II (G H P and S). | 0.999 |
CEJ88412.1 | CEJ89069.1 | HYPGJ_31798 | HYPGJ_40119 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Aminotransferase class I and II. | 0.905 |
CEJ88412.1 | hisA | HYPGJ_31798 | HYPGJ_10225 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.982 |
CEJ88412.1 | hisB | HYPGJ_31798 | HYPGJ_10219 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol-phosphate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.974 |
CEJ88412.1 | hisD | HYPGJ_31798 | HYPGJ_31632 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.990 |
CEJ88412.1 | hisE | HYPGJ_31798 | HYPGJ_10148 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosyl-ATP pyrophosphatase. | 0.990 |
CEJ88412.1 | hisF | HYPGJ_31798 | HYPGJ_10229 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.988 |
CEJ88412.1 | hisH | HYPGJ_31798 | HYPGJ_10221 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.975 |
CEJ88412.1 | hisI | HYPGJ_31798 | HYPGJ_20579 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.990 |
CEJ89069.1 | CEJ88411.1 | HYPGJ_40119 | HYPGJ_31797 | Aminotransferase class I and II. | tRNA synthetase class II (G H P and S). | 0.712 |
CEJ89069.1 | CEJ88412.1 | HYPGJ_40119 | HYPGJ_31798 | Aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.905 |