node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A067NAX7 | A0A067NG73 | A0A067NAX7 | A0A067NG73 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | MGS domain-containing protein. | 0.962 |
A0A067NAX7 | A0A067NI42 | A0A067NAX7 | A0A067NI42 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.864 |
A0A067NAX7 | A0A067NNI7 | A0A067NAX7 | A0A067NNI7 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | A_deaminase domain-containing protein. | 0.958 |
A0A067NAX7 | A0A067NRX8 | A0A067NAX7 | A0A067NRX8 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.966 |
A0A067NAX7 | A0A067NU43 | A0A067NAX7 | A0A067NU43 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | PfkB domain-containing protein. | 0.715 |
A0A067NAX7 | A0A067NYI3 | A0A067NAX7 | A0A067NYI3 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.993 |
A0A067NAX7 | A0A067P071 | A0A067NAX7 | A0A067P071 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Pribosyltran domain-containing protein. | 0.871 |
A0A067NAX7 | A0A067PCW5 | A0A067NAX7 | A0A067PCW5 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Uncharacterized protein; Belongs to the 5'-nucleotidase family. | 0.923 |
A0A067NAX7 | ADK1 | A0A067NAX7 | A0A067P416 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.664 |
A0A067NG73 | A0A067NAX7 | A0A067NG73 | A0A067NAX7 | MGS domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.962 |
A0A067NG73 | A0A067NI42 | A0A067NG73 | A0A067NI42 | MGS domain-containing protein. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.988 |
A0A067NG73 | A0A067NNI7 | A0A067NG73 | A0A067NNI7 | MGS domain-containing protein. | A_deaminase domain-containing protein. | 0.918 |
A0A067NG73 | A0A067NRX8 | A0A067NG73 | A0A067NRX8 | MGS domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.935 |
A0A067NG73 | A0A067NU43 | A0A067NG73 | A0A067NU43 | MGS domain-containing protein. | PfkB domain-containing protein. | 0.717 |
A0A067NG73 | A0A067NYI3 | A0A067NG73 | A0A067NYI3 | MGS domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.984 |
A0A067NG73 | A0A067NYS3 | A0A067NG73 | A0A067NYS3 | MGS domain-containing protein. | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. | 0.929 |
A0A067NG73 | A0A067P071 | A0A067NG73 | A0A067P071 | MGS domain-containing protein. | Pribosyltran domain-containing protein. | 0.965 |
A0A067NG73 | A0A067PCW5 | A0A067NG73 | A0A067PCW5 | MGS domain-containing protein. | Uncharacterized protein; Belongs to the 5'-nucleotidase family. | 0.915 |
A0A067NG73 | ADK1 | A0A067NG73 | A0A067P416 | MGS domain-containing protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.629 |
A0A067NI42 | A0A067NAX7 | A0A067NI42 | A0A067NAX7 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.864 |