STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)    
Predicted Functional Partners:
D778_02248
Dihydrofolate reductase.
 
 0.999
tdk
Thymidine kinase.
  
 
 0.985
D778_01892
Deoxyuridine 5'-triphosphate nucleotidohydrolase.
  
 0.984
gcvT
Aminomethyltransferase (glycine cleavage system T protein).
    
 0.962
D778_00964
Serine hydroxymethyltransferase.
  
 
 0.931
D778_02060
dCMP deaminase.
  
 
 0.930
D778_00285
Dihydrofolate synthase.
     
 0.924
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.924
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.921
surE
5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
   
 
 0.912
Your Current Organism:
Xanthomarina gelatinilytica
NCBI taxonomy Id: 1137281
Other names: Formosa sp. AK20, JCM 18821, MTCC 11705, X. gelatinilytica, Xanthomarina gelatinilytica Vaidya et al. 2015, strain AK20
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