STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AQW21785.1dUTP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 0.957
AQW22270.1
Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.957
AQW20528.1
ComE operon protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.937
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.936
PL11_003690
Carbamoyl phosphate synthase large subunit; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.920
AQW20629.1
Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
AQW21139.1
Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
     
  0.900
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.824
AQW21156.1
DNA polymerase III subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.734
AQW21784.1
Ribose 5-phosphate isomerase A; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.729
Your Current Organism:
Lactobacillus curieae
NCBI taxonomy Id: 1138822
Other names: CCTCC M 2011381, JCM 18524, L. curieae, Lactobacillus curieae Lei et al. 2013, Lactobacillus sp. CCTCC M 2011381, strain S1L19
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