ABB58506.1 protein (Synechococcus elongatus)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ABB58506.1

Conserved hypothetical protein. (111 aa)

Predicted Functional Partners:

ABB57569.1

0.706

ABB57990.1

0.652

ABB56124.1

0.640

ABB57705.1

0.582

ABB57079.1

0.580

ABB56606.1

0.578

ABB57288.1

0.578

ABB56892.1

0.576

cpcE

0.544

ABB57488.1

0.531

Your Current Organism:

Synechococcus elongatus

NCBI taxonomy Id: 1140
Other names: Anacystis nidulans R2, S. elongatus PCC 7942, Synechococcus elongatus PCC 7942, Synechococcus leopoliensis UTEX 2434, Synechococcus leopoliensis strain PCC 7942, Synechococcus sp. IAM M-200, Synechococcus sp. PCC 7942

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABB56124.1	ABB56892.1	Synpcc7942_0092	Synpcc7942_0862	Conserved hypothetical protein.	Conserved hypothetical protein.	0.660
ABB56124.1	ABB57488.1	Synpcc7942_0092	Synpcc7942_1458	Conserved hypothetical protein.	Conserved hypothetical protein.	0.400
ABB56124.1	ABB57569.1	Synpcc7942_0092	Synpcc7942_1539	Conserved hypothetical protein.	Conserved hypothetical protein.	0.698
ABB56124.1	ABB57705.1	Synpcc7942_0092	Synpcc7942_1675	Conserved hypothetical protein.	Conserved hypothetical protein.	0.486
ABB56124.1	ABB57990.1	Synpcc7942_0092	Synpcc7942_1960	Conserved hypothetical protein.	Conserved hypothetical protein.	0.652
ABB56124.1	ABB58506.1	Synpcc7942_0092	Synpcc7942_2476	Conserved hypothetical protein.	Conserved hypothetical protein.	0.640
ABB56606.1	ABB57079.1	Synpcc7942_0574	Synpcc7942_1049	Conserved hypothetical protein.	Phycobilisome rod linker polypeptide; Belongs to the phycobilisome linker protein family.	0.668
ABB56606.1	ABB58506.1	Synpcc7942_0574	Synpcc7942_2476	Conserved hypothetical protein.	Conserved hypothetical protein.	0.578
ABB56606.1	cpcE	Synpcc7942_0574	Synpcc7942_1054	Conserved hypothetical protein.	PBS lyase HEAT-like repeat; Required for the chromophorylation of the cpcA gene product. Belongs to the CpcE/RpcE/PecE family.	0.692
ABB56892.1	ABB56124.1	Synpcc7942_0862	Synpcc7942_0092	Conserved hypothetical protein.	Conserved hypothetical protein.	0.660
ABB56892.1	ABB57288.1	Synpcc7942_0862	Synpcc7942_1258	Conserved hypothetical protein.	Conserved hypothetical protein.	0.665
ABB56892.1	ABB57569.1	Synpcc7942_0862	Synpcc7942_1539	Conserved hypothetical protein.	Conserved hypothetical protein.	0.564
ABB56892.1	ABB57990.1	Synpcc7942_0862	Synpcc7942_1960	Conserved hypothetical protein.	Conserved hypothetical protein.	0.775
ABB56892.1	ABB58506.1	Synpcc7942_0862	Synpcc7942_2476	Conserved hypothetical protein.	Conserved hypothetical protein.	0.576
ABB57079.1	ABB56606.1	Synpcc7942_1049	Synpcc7942_0574	Phycobilisome rod linker polypeptide; Belongs to the phycobilisome linker protein family.	Conserved hypothetical protein.	0.668
ABB57079.1	ABB57488.1	Synpcc7942_1049	Synpcc7942_1458	Phycobilisome rod linker polypeptide; Belongs to the phycobilisome linker protein family.	Conserved hypothetical protein.	0.477
ABB57079.1	ABB58506.1	Synpcc7942_1049	Synpcc7942_2476	Phycobilisome rod linker polypeptide; Belongs to the phycobilisome linker protein family.	Conserved hypothetical protein.	0.580
ABB57079.1	cpcE	Synpcc7942_1049	Synpcc7942_1054	Phycobilisome rod linker polypeptide; Belongs to the phycobilisome linker protein family.	PBS lyase HEAT-like repeat; Required for the chromophorylation of the cpcA gene product. Belongs to the CpcE/RpcE/PecE family.	0.980
ABB57288.1	ABB56892.1	Synpcc7942_1258	Synpcc7942_0862	Conserved hypothetical protein.	Conserved hypothetical protein.	0.665
ABB57288.1	ABB57990.1	Synpcc7942_1258	Synpcc7942_1960	Conserved hypothetical protein.	Conserved hypothetical protein.	0.750

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.908

expected number of edges:

11

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000270

Peptidoglycan metabolic process

8 of 28

1.88

3.99

4.19e-11

GO:0009252

Peptidoglycan biosynthetic process

7 of 22

1.92

3.87

3.13e-10

GO:0071554

Cell wall organization or biogenesis

8 of 33

1.81

3.78

4.19e-11

GO:0008360

Regulation of cell shape

7 of 24

1.89

3.76

3.40e-10

GO:0071555

Cell wall organization

6 of 25

1.8

3.04

2.50e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

3 of 9

1.94

1.19

0.0049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3311

Mixed, incl. Regulation of cell shape, and Cell cycle

11 of 43

1.83

5.15

1.93e-17

CL:3312

Mixed, incl. Regulation of cell shape, and Peptidoglycan muralytic activity

10 of 38

1.84

4.92

7.55e-16

CL:3376

Mixed, incl. Cell cycle protein, and Serine-type exopeptidase activity

4 of 5

2.32

3.15

6.65e-07

CL:3360

Regulation of cell shape, and Peptidoglycan muralytic activity

5 of 14

1.97

3.07

1.58e-07

CL:3317

Mur ligase, central, and Glycosylation

4 of 6

2.24

3.01

1.03e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 25

1.8

2.97

4.46e-08

map00471

D-Glutamine and D-glutamate metabolism

2 of 4

2.12

1.04

0.0110

map01502

Vancomycin resistance

2 of 7

1.88

0.91

0.0175

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

6 of 15

2.02

3.67

5.59e-09

KW-0132

Cell division

6 of 22

1.86

3.19

1.92e-08

KW-0131

Cell cycle

6 of 22

1.86

3.19

1.92e-08

KW-0573

Peptidoglycan synthesis

5 of 13

2.01

3.17

1.07e-07

KW-0436

Ligase

3 of 60

1.12

0.56

0.0449

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08245

Mur ligase middle domain

3 of 5

2.2

1.58

0.00097

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.42

0.97

0.0169

PF02875

Mur ligase family, glutamate ligase domain

2 of 3

2.24

0.93

0.0187

PF01225

Mur ligase family, catalytic domain

2 of 3

2.24

0.93

0.0187

PF00905

Penicillin binding protein transpeptidase domain

2 of 4

2.12

0.92

0.0187

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013221

Mur ligase, central

3 of 4

2.3

1.48

0.0017

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.2

1.46

0.0017

IPR036565

Mur-like, catalytic domain superfamily

3 of 5

2.2

1.46

0.0017

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 2

2.42

0.89

0.0232

IPR005311

Penicillin-binding protein, dimerisation domain

2 of 2

2.42

0.89

0.0232

(more ...)

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