A0A1Y2DK67 protein (Pseudomassariella vexata)

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

A0A1Y2DK67

Uncharacterized protein. (685 aa)

Predicted Functional Partners:

A0A1Y2DNQ1

0.758

A0A1Y2EKW0

0.751

A0A1Y2EDT5

0.750

A0A1Y2EKD7

0.705

A0A1Y2DTP7

0.662

A0A1Y2DBR3

0.659

A0A1Y2E4B0

0.657

A0A1Y2DXX6

0.655

A0A1Y2EK28

0.641

A0A1Y2DJ95

0.633

Your Current Organism:

Pseudomassariella vexata

NCBI taxonomy Id: 1141098
Other names: CBS 129021, Didymella vexata, Didymosphaeria vexata, Leiosphaerella vexata, P. vexata, WU 31333

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2DBR3	A0A1Y2DJ95	SH3 domain-containing protein; Belongs to the DOCK family.	GTPase CDC42.	0.971
A0A1Y2DBR3	A0A1Y2DK67	SH3 domain-containing protein; Belongs to the DOCK family.	Uncharacterized protein.	0.659
A0A1Y2DBR3	A0A1Y2DXX6	SH3 domain-containing protein; Belongs to the DOCK family.	Rho GTPase rho1.	0.851
A0A1Y2DBR3	A0A1Y2E4B0	SH3 domain-containing protein; Belongs to the DOCK family.	Uncharacterized protein.	0.559
A0A1Y2DBR3	A0A1Y2EK28	SH3 domain-containing protein; Belongs to the DOCK family.	Small GTPase superfamily.	0.851
A0A1Y2DJ95	A0A1Y2DBR3	GTPase CDC42.	SH3 domain-containing protein; Belongs to the DOCK family.	0.971
A0A1Y2DJ95	A0A1Y2DK67	GTPase CDC42.	Uncharacterized protein.	0.633
A0A1Y2DJ95	A0A1Y2DTP7	GTPase CDC42.	Uncharacterized protein.	0.458
A0A1Y2DJ95	A0A1Y2DXX6	GTPase CDC42.	Rho GTPase rho1.	0.748
A0A1Y2DJ95	A0A1Y2E4B0	GTPase CDC42.	Uncharacterized protein.	0.505
A0A1Y2DJ95	A0A1Y2EDT5	GTPase CDC42.	Uncharacterized protein.	0.806
A0A1Y2DJ95	A0A1Y2EK28	GTPase CDC42.	Small GTPase superfamily.	0.760
A0A1Y2DJ95	A0A1Y2EKD7	GTPase CDC42.	Tropomyosin.	0.735
A0A1Y2DJ95	A0A1Y2EKW0	GTPase CDC42.	BZIP domain-containing protein.	0.691
A0A1Y2DK67	A0A1Y2DBR3	Uncharacterized protein.	SH3 domain-containing protein; Belongs to the DOCK family.	0.659
A0A1Y2DK67	A0A1Y2DJ95	Uncharacterized protein.	GTPase CDC42.	0.633
A0A1Y2DK67	A0A1Y2DNQ1	Uncharacterized protein.	Ankyrin repeat-containing domain protein.	0.758
A0A1Y2DK67	A0A1Y2DTP7	Uncharacterized protein.	Uncharacterized protein.	0.662
A0A1Y2DK67	A0A1Y2DXX6	Uncharacterized protein.	Rho GTPase rho1.	0.655
A0A1Y2DK67	A0A1Y2E4B0	Uncharacterized protein.	Uncharacterized protein.	0.657

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00014

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000096

Sulfur amino acid metabolic process

6 of 18

1.99

3.28

4.67e-08

GO:0000097

Sulfur amino acid biosynthetic process

5 of 13

2.05

2.89

7.98e-07

GO:0006534

Cysteine metabolic process

4 of 9

2.11

2.39

1.56e-05

GO:1901607

Alpha-amino acid biosynthetic process

6 of 103

1.23

1.27

8.95e-05

GO:1901605

Alpha-amino acid metabolic process

7 of 147

1.14

1.21

3.34e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

4 of 28

1.62

1.28

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2328

Cysteine and methionine metabolism, and L-serine metabolic process

5 of 20

1.86

2.47

3.00e-06

CL:2329

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, and Cysteine and methionine metabolism

4 of 11

2.02

2.31

1.79e-05

CL:2332

Sulfur amino acid biosynthetic process, and Potassium

3 of 5

2.24

1.93

0.00020

CL:2257

Glycine, serine and threonine metabolism, and Sulfur amino acid metabolic process

6 of 64

1.44

1.76

8.74e-06

CL:2105

Alpha-amino acid metabolic process, and Glycine, serine and threonine metabolism

8 of 140

1.22

1.5

1.77e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

8 of 41

1.75

3.65

3.23e-11

map01230

Biosynthesis of amino acids

8 of 154

1.18

1.5

3.21e-07

map00450

Selenocompound metabolism

3 of 18

1.69

1.4

0.00096

map00920

Sulfur metabolism

3 of 38

1.36

0.94

0.0062

map00260

Glycine, serine and threonine metabolism

3 of 67

1.11

0.63

0.0258

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

3 of 5

2.24

1.65

0.00074

PF01842

ACT domain

2 of 5

2.07

0.7

0.0497

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001926

Tryptophan synthase beta chain-like, PALP domain

3 of 5

2.24

1.42

0.0021

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

3 of 6

2.16

1.41

0.0021

IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

2 of 2

2.46

0.86

0.0265

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

3 of 25

1.54

0.75

0.0291

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 27

1.51

0.74

0.0291

(more ...)

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