A0A1Y2DQ76 protein (Pseudomassariella vexata)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

A0A1Y2DQ76

Six-hairpin glycosidase-like protein. (693 aa)

Predicted Functional Partners:

A0A1Y2DM54

0.818

A0A1Y2DZS0

0.818

A0A1Y2DFU2

0.812

A0A1Y2DLY6

0.597

A0A1Y2D714

0.539

A0A1Y2DDP2

0.539

A0A1Y2DVU6

0.539

A0A1Y2E411

0.539

A0A1Y2E682

0.539

A0A1Y2EKE9

0.539

Your Current Organism:

Pseudomassariella vexata

NCBI taxonomy Id: 1141098
Other names: CBS 129021, Didymella vexata, Didymosphaeria vexata, Leiosphaerella vexata, P. vexata, WU 31333

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2D714	A0A1Y2DDP2	U3 small nucleolar RNA associated protein.	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.999
A0A1Y2D714	A0A1Y2DLY6	U3 small nucleolar RNA associated protein.	Armadillo-type protein.	0.999
A0A1Y2D714	A0A1Y2DQ76	U3 small nucleolar RNA associated protein.	Six-hairpin glycosidase-like protein.	0.539
A0A1Y2D714	A0A1Y2DVU6	U3 small nucleolar RNA associated protein.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.997
A0A1Y2D714	A0A1Y2E411	U3 small nucleolar RNA associated protein.	Nucleolar complex protein.	0.999
A0A1Y2D714	A0A1Y2E682	U3 small nucleolar RNA associated protein.	Alpha/beta knot methyltransferase.	0.998
A0A1Y2D714	A0A1Y2EKE9	U3 small nucleolar RNA associated protein.	Fcf1-domain-containing protein.	0.998
A0A1Y2DDP2	A0A1Y2D714	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	U3 small nucleolar RNA associated protein.	0.999
A0A1Y2DDP2	A0A1Y2DLY6	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	Armadillo-type protein.	0.998
A0A1Y2DDP2	A0A1Y2DQ76	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	Six-hairpin glycosidase-like protein.	0.539
A0A1Y2DDP2	A0A1Y2DVU6	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.997
A0A1Y2DDP2	A0A1Y2E411	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	Nucleolar complex protein.	0.999
A0A1Y2DDP2	A0A1Y2E682	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	Alpha/beta knot methyltransferase.	0.998
A0A1Y2DDP2	A0A1Y2EKE9	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	Fcf1-domain-containing protein.	0.999
A0A1Y2DFU2	A0A1Y2DM54	Uncharacterized protein.	Uncharacterized protein.	0.510
A0A1Y2DFU2	A0A1Y2DQ76	Uncharacterized protein.	Six-hairpin glycosidase-like protein.	0.812
A0A1Y2DFU2	A0A1Y2DZS0	Uncharacterized protein.	Glycerophosphoryl diester phosphodiesterase family-domain-containing protein.	0.510
A0A1Y2DLY6	A0A1Y2D714	Armadillo-type protein.	U3 small nucleolar RNA associated protein.	0.999
A0A1Y2DLY6	A0A1Y2DDP2	Armadillo-type protein.	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.998
A0A1Y2DLY6	A0A1Y2DQ76	Armadillo-type protein.	Six-hairpin glycosidase-like protein.	0.597

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.558

expected number of edges:

10

PPI enrichment p-value:

3.56e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045893

Positive regulation of transcription, DNA-templated

6 of 212

1.91

2.99

1.52e-07

GO:0045944

Positive regulation of transcription by RNA polymerase II

5 of 170

1.93

2.9

3.28e-07

GO:0006357

Regulation of transcription by RNA polymerase II

7 of 675

1.48

2.18

1.55e-07

GO:0006355

Regulation of transcription, DNA-templated

8 of 949

1.39

1.99

1.52e-07

GO:0010468

Regulation of gene expression

9 of 1607

1.21

1.6

1.52e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046982

Protein heterodimerization activity

5 of 46

2.5

4.35

3.28e-09

GO:0046983

Protein dimerization activity

6 of 112

2.19

4.13

1.71e-09

GO:0003700

DNA-binding transcription factor activity

5 of 404

1.56

1.7

6.14e-05

GO:0043565

Sequence-specific DNA binding

5 of 411

1.55

1.69

6.14e-05

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 of 83

2.02

1.62

0.00064

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016602

CCAAT-binding factor complex

3 of 4

3.34

3.35

8.72e-07

GO:0005667

Transcription regulator complex

4 of 98

2.07

2.4

1.30e-05

GO:0140513

Nuclear protein-containing complex

5 of 894

1.21

1.03

0.0012

GO:0005634

Nucleus

9 of 4254

0.79

0.7

0.00016

GO:0032991

Protein-containing complex

6 of 3129

0.75

0.46

0.0242

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24966

Mixed, incl. Homeobox, and Zinc finger, GATA-type

7 of 83

2.39

5.74

1.16e-12

CL:25072

Mixed, incl. Zinc finger, GATA-type, and Transcription factor CBF/NF-Y/archaeal histone domain

5 of 26

2.75

5.33

7.49e-11

CL:25102

Mixed, incl. CCAAT-binding factor complex, and CMG complex assembly

4 of 11

3.02

4.69

2.36e-09

CL:25105

CCAAT-binding factor complex, and CMG complex assembly

3 of 6

3.16

3.45

5.41e-07

CL:24973

Mixed, incl. Homeobox, and Fertilization

2 of 33

2.25

1.02

0.0127

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05152

Tuberculosis

3 of 6

3.16

3.53

3.85e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-381042

PERK regulates gene expression

3 of 6

3.16

3.09

2.44e-06

MAP-381033

ATF6 (ATF6-alpha) activates chaperones

3 of 10

2.94

4.15e-06

MAP-381119

Unfolded Protein Response (UPR)

3 of 60

2.16

1.77

0.00038

MAP-8957322

Metabolism of steroids

3 of 175

1.7

1.11

0.0052

MAP-212436

Generic Transcription Pathway

4 of 508

1.36

0.97

0.0047

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

7 of 432

1.67

2.91

6.69e-09

KW-0238

DNA-binding

3 of 202

1.63

1.09

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00808

Histone-like transcription factor (CBF/NF-Y) and archaeal histone

4 of 8

3.16

4.55

4.91e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003958

Transcription factor CBF/NF-Y/archaeal histone domain

4 of 8

3.16

4.49

6.46e-09

IPR009072

Histone-fold

5 of 38

2.58

4.31

5.48e-09

IPR027113

Transcription factor NFYB/HAP3

2 of 2

3.46

1.74

0.00074

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