A0A1Y2DQL9 protein (Pseudomassariella vexata)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A1Y2DQL9

Uncharacterized protein. (98 aa)

Predicted Functional Partners:

A0A1Y2EEU3

0.531

A0A1Y2E540

0.488

A0A1Y2E382

0.484

A0A1Y2DDY7

0.466

A0A1Y2DD79

0.443

A0A1Y2DKK0

0.430

Your Current Organism:

Pseudomassariella vexata

NCBI taxonomy Id: 1141098
Other names: CBS 129021, Didymella vexata, Didymosphaeria vexata, Leiosphaerella vexata, P. vexata, WU 31333

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2DD79	A0A1Y2DQL9	Histidine biosynthesis trifunctional protein.	Uncharacterized protein.	0.443
A0A1Y2DDY7	A0A1Y2DKK0	Cytochrome c oxidase copper chaperone.	CHCH domain-containing protein.	0.967
A0A1Y2DDY7	A0A1Y2DQL9	Cytochrome c oxidase copper chaperone.	Uncharacterized protein.	0.466
A0A1Y2DDY7	A0A1Y2E540	Cytochrome c oxidase copper chaperone.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.521
A0A1Y2DDY7	A0A1Y2EEU3	Cytochrome c oxidase copper chaperone.	Armadillo-type protein.	0.898
A0A1Y2DKK0	A0A1Y2DDY7	CHCH domain-containing protein.	Cytochrome c oxidase copper chaperone.	0.967
A0A1Y2DKK0	A0A1Y2DQL9	CHCH domain-containing protein.	Uncharacterized protein.	0.430
A0A1Y2DQL9	A0A1Y2DD79	Uncharacterized protein.	Histidine biosynthesis trifunctional protein.	0.443
A0A1Y2DQL9	A0A1Y2DDY7	Uncharacterized protein.	Cytochrome c oxidase copper chaperone.	0.466
A0A1Y2DQL9	A0A1Y2DKK0	Uncharacterized protein.	CHCH domain-containing protein.	0.430
A0A1Y2DQL9	A0A1Y2E382	Uncharacterized protein.	Uncharacterized protein.	0.484
A0A1Y2DQL9	A0A1Y2E540	Uncharacterized protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.488
A0A1Y2DQL9	A0A1Y2EEU3	Uncharacterized protein.	Armadillo-type protein.	0.531
A0A1Y2E382	A0A1Y2DQL9	Uncharacterized protein.	Uncharacterized protein.	0.484
A0A1Y2E540	A0A1Y2DDY7	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Cytochrome c oxidase copper chaperone.	0.521
A0A1Y2E540	A0A1Y2DQL9	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Uncharacterized protein.	0.488
A0A1Y2E540	A0A1Y2EEU3	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Armadillo-type protein.	0.531
A0A1Y2EEU3	A0A1Y2DDY7	Armadillo-type protein.	Cytochrome c oxidase copper chaperone.	0.898
A0A1Y2EEU3	A0A1Y2DQL9	Armadillo-type protein.	Uncharacterized protein.	0.531
A0A1Y2EEU3	A0A1Y2E540	Armadillo-type protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.531

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

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