A0A1Y2EA53 protein (Pseudomassariella vexata)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

A0A1Y2EA53

Pre-rRNA processing nucleolar protein-like protein Sik1. (514 aa)

Predicted Functional Partners:

A0A1Y2DLD7

0.999

A0A1Y2E015

0.999

A0A1Y2EBQ9

0.999

A0A1Y2EJP1

0.999

A0A1Y2EL58

0.999

A0A1Y2DIL6

0.998

A0A1Y2DXA2

0.998

A0A1Y2E1D5

0.998

A0A1Y2DLM7

0.997

A0A1Y2DV16

0.997

Your Current Organism:

Pseudomassariella vexata

NCBI taxonomy Id: 1141098
Other names: CBS 129021, Didymella vexata, Didymosphaeria vexata, Leiosphaerella vexata, P. vexata, WU 31333

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2DIL6	A0A1Y2DLD7	U3 small nucleolar RNA-associated protein 10.	Ribosome biogenesis protein.	0.999
A0A1Y2DIL6	A0A1Y2DLM7	U3 small nucleolar RNA-associated protein 10.	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.	0.998
A0A1Y2DIL6	A0A1Y2DV16	U3 small nucleolar RNA-associated protein 10.	Utp21 specific WD40 associated putative domain-domain-containing protein.	0.999
A0A1Y2DIL6	A0A1Y2DXA2	U3 small nucleolar RNA-associated protein 10.	Dip2/Utp12 family-domain-containing protein.	0.999
A0A1Y2DIL6	A0A1Y2E015	U3 small nucleolar RNA-associated protein 10.	AARP2CN domain-containing protein.	0.999
A0A1Y2DIL6	A0A1Y2E1D5	U3 small nucleolar RNA-associated protein 10.	Putative small nucleolar ribonucleo protein complex subunit Utp15.	0.999
A0A1Y2DIL6	A0A1Y2EA53	U3 small nucleolar RNA-associated protein 10.	Pre-rRNA processing nucleolar protein-like protein Sik1.	0.998
A0A1Y2DIL6	A0A1Y2EBQ9	U3 small nucleolar RNA-associated protein 10.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.987
A0A1Y2DIL6	A0A1Y2EJP1	U3 small nucleolar RNA-associated protein 10.	Fibrillarin-domain-containing protein.	0.997
A0A1Y2DIL6	A0A1Y2EL58	U3 small nucleolar RNA-associated protein 10.	WD40-repeat-containing domain protein.	0.998
A0A1Y2DLD7	A0A1Y2DIL6	Ribosome biogenesis protein.	U3 small nucleolar RNA-associated protein 10.	0.999
A0A1Y2DLD7	A0A1Y2DLM7	Ribosome biogenesis protein.	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.	0.998
A0A1Y2DLD7	A0A1Y2DV16	Ribosome biogenesis protein.	Utp21 specific WD40 associated putative domain-domain-containing protein.	0.998
A0A1Y2DLD7	A0A1Y2DXA2	Ribosome biogenesis protein.	Dip2/Utp12 family-domain-containing protein.	0.999
A0A1Y2DLD7	A0A1Y2E015	Ribosome biogenesis protein.	AARP2CN domain-containing protein.	0.998
A0A1Y2DLD7	A0A1Y2E1D5	Ribosome biogenesis protein.	Putative small nucleolar ribonucleo protein complex subunit Utp15.	0.999
A0A1Y2DLD7	A0A1Y2EA53	Ribosome biogenesis protein.	Pre-rRNA processing nucleolar protein-like protein Sik1.	0.999
A0A1Y2DLD7	A0A1Y2EBQ9	Ribosome biogenesis protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.999
A0A1Y2DLD7	A0A1Y2EJP1	Ribosome biogenesis protein.	Fibrillarin-domain-containing protein.	0.999
A0A1Y2DLD7	A0A1Y2EL58	Ribosome biogenesis protein.	WD40-repeat-containing domain protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.865

expected number of edges:

11

PPI enrichment p-value:

0.000495

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006368

Transcription elongation from RNA polymerase II promoter

6 of 24

2.31

4.32

1.40e-09

GO:0016570

Histone modification

6 of 92

1.72

2.48

7.50e-07

GO:0032968

Positive regulation of transcription elongation from RNA polymerase II promoter

3 of 13

2.27

1.94

0.00020

GO:0034402

Recruitment of 3-end processing factors to RNA polymerase II holoenzyme complex

2 of 5

2.51

1.32

0.0038

GO:0070478

Nuclear-transcribed mRNA catabolic process, 3-5 exonucleolytic nonsense-mediated decay

2 of 8

2.31

1.15

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

6 of 14

2.54

5.28

3.99e-11

GO:0005515

Protein binding

8 of 738

0.94

0.91

6.82e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.18

1.66e-12

GO:0055087

Ski complex

2 of 3

2.73

1.65

0.00096

GO:0032991

Protein-containing complex

10 of 1771

0.66

0.58

8.35e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1768

RNA Polymerase II Transcription Elongation

6 of 28

2.24

4.23

1.43e-09

CL:1810

Cdc73/Paf1 complex

4 of 6

2.73

3.73

1.06e-07

CL:681

COP9 signalosome, and Cul4-RING E3 ubiquitin ligase complex

3 of 20

2.08

1.72

0.00044

CL:5095

mRNA decay by 3 to 5 exoribonuclease

2 of 17

1.98

0.8

0.0316

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.65

8.49e-09

MAP-674695

RNA Polymerase II Pre-transcription Events

6 of 67

1.86

3.06

5.11e-08

MAP-73857

RNA Polymerase II Transcription

6 of 389

1.1

0.95

0.00087

MAP-74160

Gene expression (Transcription)

6 of 523

0.97

0.73

0.0035

MAP-8866654

E3 ubiquitin ligases ubiquitinate target proteins

2 of 17

1.98

0.73

0.0435

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.15

1.92e-12

GOCC:0055087

Ski complex

2 of 2

2.91

1.71

0.00080

GOCC:0032991

Protein-containing complex

9 of 2171

0.53

0.38

0.0083

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