STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sufAIron-sulfur cluster assembly scaffold protein; Belongs to the HesB/IscA family. (129 aa)    
Predicted Functional Partners:
OOA_07270
Cysteine desulfurase activator complex subunit SufB; COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.957
sufC
Cysteine desulfurase ATPase component; COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component.
 
 
 0.886
OOA_07260
Cysteine desulfurase activator complex subunit SufD; COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.877
hscB
Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
 
 0.850
OOA_02662
Iron-binding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.806
OOA_07255
Bifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
 
 
 0.805
OOA_02682
(2Fe-2S)-binding protein; COG0633 Ferredoxin.
  
 
 0.789
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.772
OOA_07188
Glutaredoxin-4; COG0278 Glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily.
 
 0.747
OOA_05696
COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
 
  
 0.744
Your Current Organism:
Providencia burhodogranariea
NCBI taxonomy Id: 1141662
Other names: P. burhodogranariea DSM 19968, Providencia burhodogranariea DSM 19968, Providencia burhodogranariea str. B, Providencia burhodogranariea str. DSM 19968, Providencia burhodogranariea strain DSM 19968
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.