STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OOA_17580Aminoacyl-histidine dipeptidase; COG2195 Di- and tripeptidases. (486 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.783
pepA
Multifunctional aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
   
 
 0.691
guaB
Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 
 0.686
OOA_03369
Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase.
   
  0.680
pepN
COG0308 Aminopeptidase N.
     
 0.678
OOA_02692
Aminopeptidase B; Probably plays an important role in intracellular peptide degradation.
   
 
 0.668
OOA_16804
Gamma-glutamyltranspeptidase; COG0405 Gamma-glutamyltransferase.
     
 0.665
gshB
COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family.
     
 0.665
OOA_17864
COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
    
  0.659
gshA
Glutamate--cysteine ligase; COG2918 Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
   
 
 0.650
Your Current Organism:
Providencia burhodogranariea
NCBI taxonomy Id: 1141662
Other names: P. burhodogranariea DSM 19968, Providencia burhodogranariea DSM 19968, Providencia burhodogranariea str. B, Providencia burhodogranariea str. DSM 19968, Providencia burhodogranariea strain DSM 19968
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