nfrB3 protein (Corallococcus coralloides) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nfrB3

GspE N-terminal domain-containing protein. (336 aa)

Predicted Functional Partners:

pilC

0.884

gspF

0.861

AFE05167.1

0.770

pilD

0.722

AFE06211.1

0.710

pilT2

0.697

pilT

0.692

comEC

0.651

pilM

0.648

pilT1

0.637

Your Current Organism:

Corallococcus coralloides

NCBI taxonomy Id: 1144275
Other names: C. coralloides DSM 2259, Corallococcus coralloides ATCC 25202, Corallococcus coralloides DSM 2259, Corallococcus coralloides NBRC 100086, Corallococcus coralloides str. DSM 2259, Corallococcus coralloides strain DSM 2259

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFE05167.1	comEC	COCOR_03346	COCOR_05417	General secretion pathway protein E.	DNA internalization-related competence protein.	0.635
AFE05167.1	gspF	COCOR_03346	COCOR_05577	General secretion pathway protein E.	General secretion pathway protein F.	0.769
AFE05167.1	nfrB3	COCOR_03346	COCOR_08091	General secretion pathway protein E.	GspE N-terminal domain-containing protein.	0.770
AFE05167.1	pilC	COCOR_03346	COCOR_06286	General secretion pathway protein E.	Type 4 fimbrial assembly protein PilC.	0.824
AFE05167.1	pilD	COCOR_03346	COCOR_06279	General secretion pathway protein E.	Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.594
AFE05167.1	pilM	COCOR_03346	COCOR_06276	General secretion pathway protein E.	Type IV pilus assembly protein PilM.	0.695
AFE05167.1	pilT	COCOR_03346	COCOR_02013	General secretion pathway protein E.	Twitching mobility protein.	0.490
AFE05167.1	pilT2	COCOR_03346	COCOR_06287	General secretion pathway protein E.	Twitching motility protein.	0.515
AFE06211.1	comEC	COCOR_05138	COCOR_05417	General secretion pathway protein E.	DNA internalization-related competence protein.	0.624
AFE06211.1	gspF	COCOR_05138	COCOR_05577	General secretion pathway protein E.	General secretion pathway protein F.	0.703
AFE06211.1	nfrB3	COCOR_05138	COCOR_08091	General secretion pathway protein E.	GspE N-terminal domain-containing protein.	0.710
AFE06211.1	pilC	COCOR_05138	COCOR_06286	General secretion pathway protein E.	Type 4 fimbrial assembly protein PilC.	0.746
AFE06211.1	pilD	COCOR_05138	COCOR_06279	General secretion pathway protein E.	Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.476
AFE06211.1	pilM	COCOR_05138	COCOR_06276	General secretion pathway protein E.	Type IV pilus assembly protein PilM.	0.702
comEC	AFE05167.1	COCOR_05417	COCOR_03346	DNA internalization-related competence protein.	General secretion pathway protein E.	0.635
comEC	AFE06211.1	COCOR_05417	COCOR_05138	DNA internalization-related competence protein.	General secretion pathway protein E.	0.624
comEC	gspF	COCOR_05417	COCOR_05577	DNA internalization-related competence protein.	General secretion pathway protein F.	0.715
comEC	nfrB3	COCOR_05417	COCOR_08091	DNA internalization-related competence protein.	GspE N-terminal domain-containing protein.	0.651
comEC	pilC	COCOR_05417	COCOR_06286	DNA internalization-related competence protein.	Type 4 fimbrial assembly protein PilC.	0.715
comEC	pilD	COCOR_05417	COCOR_06279	DNA internalization-related competence protein.	Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.702

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

16

PPI enrichment p-value:

5.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

9 of 110

1.51

2.68

4.74e-10

GO:0044718

Siderophore transmembrane transport

3 of 20

1.77

1.29

0.0023

GO:0055085

Transmembrane transport

8 of 414

0.88

0.81

0.00015

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

3 of 4

2.47

2.12

0.00011

GO:0015343

Siderophore transmembrane transporter activity

3 of 28

1.63

0.97

0.0100

GO:0022857

Transmembrane transporter activity

9 of 432

0.92

0.9

3.60e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

3 of 44

1.43

1.03

0.0042

GO:0005886

Plasma membrane

9 of 653

0.74

0.64

0.00023

GO:0016021

Integral component of membrane

9 of 967

0.57

0.44

0.0022

GO:0016020

Membrane

10 of 1384

0.46

0.37

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5771

Mixed, incl. TonB, C-terminal, and MotA/TolQ/ExbB proton channel

9 of 20

2.25

6.96

6.73e-17

CL:5772

Mixed, incl. MotA/TolQ/ExbB proton channel, and Energy transducer activity

7 of 13

2.33

5.82

3.74e-13

CL:5763

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

11 of 63

1.84

5.22

1.49e-17

CL:5764

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

10 of 56

1.85

5.01

4.05e-16

CL:5786

Mixed, incl. Putative MotA/TolQ/ExbB family protein, and Energy transducer activity

5 of 6

2.52

4.56

1.30e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01503

Cationic antimicrobial peptide (CAMP) resistance

5 of 88

1.35

1.33

0.00022

map02010

ABC transporters

5 of 166

1.08

0.86

0.0022

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

9 of 45

1.9

4.8

4.36e-14

KW-0735

Signal-anchor

3 of 5

2.38

2.25

5.28e-05

KW-0997

Cell inner membrane

3 of 81

1.17

0.59

0.0404

KW-0812

Transmembrane

9 of 949

0.57

0.44

0.0024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02472

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.82

2.91e-08

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 7

2.23

1.75

0.00046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003400

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.63

7.46e-08

IPR003538

Gram-negative bacterial TonB protein

3 of 4

2.47

1.86

0.00035

IPR037682

TonB, C-terminal

3 of 7

2.23

1.63

0.00079

IPR006260

TonB/TolA, C-terminal

3 of 7

2.23

1.63

0.00079

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