node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EJL21004.1 | EJL24115.1 | PMI02_05328 | PMI02_03822 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 0.446 |
EJL21004.1 | EJL33327.1 | PMI02_05328 | PMI02_01172 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | PFAM: Small subunit of acetolactate synthase, ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.924 |
EJL21004.1 | EJL33845.1 | PMI02_05328 | PMI02_00929 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | PFAM: Pyruvate kinase, barrel domain, Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. | 0.975 |
EJL21004.1 | EJL34001.1 | PMI02_05328 | PMI02_00884 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit. | 0.809 |
EJL21004.1 | ilvC | PMI02_05328 | PMI02_01173 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.460 |
EJL21004.1 | leuA | PMI02_05328 | PMI02_02378 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.893 |
EJL21004.1 | leuB | PMI02_05328 | PMI02_00729 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.427 |
EJL21004.1 | leuC | PMI02_05328 | PMI02_00863 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.663 |
EJL21004.1 | leuC-2 | PMI02_05328 | PMI02_04696 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.870 |
EJL21004.1 | leuD-2 | PMI02_05328 | PMI02_04694 | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.871 |
EJL24115.1 | EJL21004.1 | PMI02_03822 | PMI02_05328 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 0.446 |
EJL24115.1 | EJL33327.1 | PMI02_03822 | PMI02_01172 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | PFAM: Small subunit of acetolactate synthase, ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.857 |
EJL24115.1 | EJL34001.1 | PMI02_03822 | PMI02_00884 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit. | 0.460 |
EJL24115.1 | ilvC | PMI02_03822 | PMI02_01173 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.870 |
EJL24115.1 | leuA | PMI02_03822 | PMI02_02378 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.484 |
EJL24115.1 | leuB | PMI02_03822 | PMI02_00729 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.595 |
EJL24115.1 | leuC | PMI02_03822 | PMI02_00863 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.464 |
EJL24115.1 | leuC-2 | PMI02_03822 | PMI02_04696 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.478 |
EJL24115.1 | leuD-2 | PMI02_03822 | PMI02_04694 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.887 |
EJL33327.1 | EJL21004.1 | PMI02_01172 | PMI02_05328 | PFAM: Small subunit of acetolactate synthase, ACT domain; TIGRFAM: acetolactate synthase, small subunit. | Malic enzyme; PFAM: Phosphate acetyl/butaryl transferase, Malic enzyme, NAD binding domain, Malic enzyme, N-terminal domain. | 0.924 |