STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pncANicotinamidase/pyrazinamidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (211 aa)    
Predicted Functional Partners:
pncB
Nicotinate phosphoribosyltransferase (NAPRTase); Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
 
 
 0.987
cobB-2
Putative transciptional regulatory Sir2-family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
   
 0.910
BRADO2114
Putative Isoquinoline 1-oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
    
  0.904
BRADO2115
Putative isoquinoline 1-oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
  0.902
BRADO3161
Putative oxidoreductase subunit protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
  0.902
BRADO3160
Putative oxidoreductase subunit protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
    
  0.900
nadE
Glutamine-dependent NAD(+) synthetase (EC 6.3.5. 1) (NAD(+) synthase [glutamine-hydrolyzing]); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
 
 0.712
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
    0.537
trmJ
Putative tRNA/rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
      0.479
BRADO2105
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.470
Your Current Organism:
Bradyrhizobium sp. ORS278
NCBI taxonomy Id: 114615
Other names: B. sp. ORS 278, Bradyrhizobium sp. ORS 278
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