node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRADO2166 | dut | BRADO2166 | BRADO0078 | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
BRADO2166 | surE | BRADO2166 | BRADO4042 | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
BRADO2166 | thyA | BRADO2166 | BRADO5578 | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5'-nucleotidase family. | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.907 |
BRADO2166 | tmk | BRADO2166 | BRADO3827 | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
BRADO3826 | BRADO3828 | BRADO3826 | BRADO3828 | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.815 |
BRADO3826 | BRADO3830 | BRADO3826 | BRADO3830 | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.640 |
BRADO3826 | metG | BRADO3826 | BRADO3829 | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | Methionyl-tRNA synthetase (EC 6.1.1.10); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.642 |
BRADO3826 | tmk | BRADO3826 | BRADO3827 | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.803 |
BRADO3828 | BRADO3826 | BRADO3828 | BRADO3826 | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | 0.815 |
BRADO3828 | BRADO3830 | BRADO3828 | BRADO3830 | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.696 |
BRADO3828 | metG | BRADO3828 | BRADO3829 | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Methionyl-tRNA synthetase (EC 6.1.1.10); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.704 |
BRADO3828 | tmk | BRADO3828 | BRADO3827 | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.844 |
BRADO3830 | BRADO3826 | BRADO3830 | BRADO3826 | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Serine-type D-Ala-D-Ala carboxypeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the peptidase S11 family. | 0.640 |
BRADO3830 | BRADO3828 | BRADO3830 | BRADO3828 | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative DNA polymerase III, delta prime subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.696 |
BRADO3830 | metG | BRADO3830 | BRADO3829 | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionyl-tRNA synthetase (EC 6.1.1.10); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.969 |
BRADO3830 | tmk | BRADO3830 | BRADO3827 | Putative deoxyribonuclease (ycfH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.706 |
dut | BRADO2166 | BRADO0078 | BRADO2166 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5'-nucleotidase family. | 0.900 |
dut | ndk | BRADO0078 | BRADO3334 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.942 |
dut | nrd | BRADO0078 | BRADO3475 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Ribonucleotide reductase large subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.759 |
dut | surE | BRADO0078 | BRADO4042 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |