node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRADO0131 | queA | BRADO0131 | BRADO3993 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.843 |
BRADO0131 | queC | BRADO0131 | BRADO3849 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.533 |
BRADO0131 | queE | BRADO0131 | BRADO1974 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.427 |
BRADO0131 | queF | BRADO0131 | BRADO4095 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.584 |
BRADO0131 | tgt | BRADO0131 | BRADO3990 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | tRNA-guanine transglycosylase (queuine/archaeosine tRNA-ribosyltransferase); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophil [...] | 0.496 |
BRADO1973 | BRADO3851 | BRADO1973 | BRADO3851 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Protein mazG; Function of strongly homologous gene. | 0.435 |
BRADO1973 | queA | BRADO1973 | BRADO3993 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.431 |
BRADO1973 | queC | BRADO1973 | BRADO3849 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.937 |
BRADO1973 | queE | BRADO1973 | BRADO1974 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.997 |
BRADO1973 | queF | BRADO1973 | BRADO4095 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.862 |
BRADO1973 | tgt | BRADO1973 | BRADO3990 | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | tRNA-guanine transglycosylase (queuine/archaeosine tRNA-ribosyltransferase); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophil [...] | 0.428 |
BRADO2133 | BRADO3851 | BRADO2133 | BRADO3851 | Putative GTP cyclohydrolase II, riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Protein mazG; Function of strongly homologous gene. | 0.836 |
BRADO2133 | queC | BRADO2133 | BRADO3849 | Putative GTP cyclohydrolase II, riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.442 |
BRADO2133 | queF | BRADO2133 | BRADO4095 | Putative GTP cyclohydrolase II, riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.547 |
BRADO2133 | tgt | BRADO2133 | BRADO3990 | Putative GTP cyclohydrolase II, riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | tRNA-guanine transglycosylase (queuine/archaeosine tRNA-ribosyltransferase); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophil [...] | 0.533 |
BRADO3851 | BRADO1973 | BRADO3851 | BRADO1973 | Protein mazG; Function of strongly homologous gene. | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.435 |
BRADO3851 | BRADO2133 | BRADO3851 | BRADO2133 | Protein mazG; Function of strongly homologous gene. | Putative GTP cyclohydrolase II, riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.836 |
BRADO3851 | queC | BRADO3851 | BRADO3849 | Protein mazG; Function of strongly homologous gene. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.714 |
queA | BRADO0131 | BRADO3993 | BRADO0131 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.843 |
queA | BRADO1973 | BRADO3993 | BRADO1973 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative 6-pyruvoyltetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.431 |