node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRADO2458 | BRADO4696 | BRADO2458 | BRADO4696 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.690 |
BRADO2458 | ilvC | BRADO2458 | BRADO5559 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.846 |
BRADO2458 | leuA | BRADO2458 | BRADO5528 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.739 |
BRADO2458 | leuB | BRADO2458 | BRADO0353 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.919 |
BRADO2458 | leuC | BRADO2458 | BRADO0374 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.988 |
BRADO2458 | leuC-2 | BRADO2458 | BRADO5516 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-isopropylmalate dehydratase (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.991 |
BRADO2458 | leuD | BRADO2458 | BRADO0365 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.983 |
BRADO2458 | leuD-2 | BRADO2458 | BRADO5517 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.987 |
BRADO2458 | nifV | BRADO2458 | BRADO5390 | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Homocitrate synthase; Function of strongly homologous gene; enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.790 |
BRADO4696 | BRADO2458 | BRADO4696 | BRADO2458 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.690 |
BRADO4696 | ilvC | BRADO4696 | BRADO5559 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.788 |
BRADO4696 | leuA | BRADO4696 | BRADO5528 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.918 |
BRADO4696 | leuB | BRADO4696 | BRADO0353 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.753 |
BRADO4696 | leuC | BRADO4696 | BRADO0374 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.975 |
BRADO4696 | leuC-2 | BRADO4696 | BRADO5516 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.974 |
BRADO4696 | leuD | BRADO4696 | BRADO0365 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.975 |
BRADO4696 | leuD-2 | BRADO4696 | BRADO5517 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.974 |
BRADO4696 | nifV | BRADO4696 | BRADO5390 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homocitrate synthase; Function of strongly homologous gene; enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.926 |
BRADO4696 | poxB | BRADO4696 | BRADO6642 | Putative isopropylmalate synthase (LeuA-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate dehydrogenase/oxidase: FAD-and thiamin PPi-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family. | 0.867 |
ilvC | BRADO2458 | BRADO5559 | BRADO2458 | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Putative 3-isopropylmalate dehydrogenase (leuB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.846 |