node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIE73173.1 | AIE73683.1 | D082_06440 | D082_11550 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Pterin-binding family; Sly2000070. | 0.449 |
AIE73173.1 | folB | D082_06440 | D082_27020 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.498 |
AIE73173.1 | folC | D082_06440 | D082_30140 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydrofolate synthase / Folylpolyglutamate synthase; Sly1006130; Belongs to the folylpolyglutamate synthase family. | 0.458 |
AIE73173.1 | folE | D082_06440 | D082_07240 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I type 1; Sly3000700. | 0.527 |
AIE73173.1 | folK | D082_06440 | D082_12040 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Sly1025160. | 0.526 |
AIE73173.1 | folP | D082_06440 | D082_17850 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.449 |
AIE73173.1 | ribD | D082_06440 | D082_14580 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.455 |
AIE73683.1 | AIE73173.1 | D082_11550 | D082_06440 | Pterin-binding family; Sly2000070. | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.449 |
AIE73683.1 | folB | D082_11550 | D082_27020 | Pterin-binding family; Sly2000070. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.789 |
AIE73683.1 | folC | D082_11550 | D082_30140 | Pterin-binding family; Sly2000070. | Dihydrofolate synthase / Folylpolyglutamate synthase; Sly1006130; Belongs to the folylpolyglutamate synthase family. | 0.513 |
AIE73683.1 | folE | D082_11550 | D082_07240 | Pterin-binding family; Sly2000070. | GTP cyclohydrolase I type 1; Sly3000700. | 0.789 |
AIE73683.1 | folK | D082_11550 | D082_12040 | Pterin-binding family; Sly2000070. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Sly1025160. | 0.789 |
AIE73683.1 | ribD | D082_11550 | D082_14580 | Pterin-binding family; Sly2000070. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.451 |
AIE73731.1 | folK | D082_12030 | D082_12040 | Hypothetical protein; Sly1025150. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Sly1025160. | 0.463 |
folB | AIE73173.1 | D082_27020 | D082_06440 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.498 |
folB | AIE73683.1 | D082_27020 | D082_11550 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Pterin-binding family; Sly2000070. | 0.789 |
folB | folC | D082_27020 | D082_30140 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate synthase / Folylpolyglutamate synthase; Sly1006130; Belongs to the folylpolyglutamate synthase family. | 0.802 |
folB | folE | D082_27020 | D082_07240 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I type 1; Sly3000700. | 0.983 |
folB | folK | D082_27020 | D082_12040 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Sly1025160. | 0.998 |
folB | folP | D082_27020 | D082_17850 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.990 |