| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | guaA | D082_04420 | D082_10940 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.862 |
| apt | guaB-2 | D082_04420 | D082_32460 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | 0.530 |
| apt | purB | D082_04420 | D082_05960 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.975 |
| apt | surE | D082_04420 | D082_16750 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
| apt | surE-2 | D082_04420 | D082_31270 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5-nucleotidase SurE; Sly1005000. | 0.915 |
| dgt | surE | D082_06310 | D082_16750 | dNTP triphosphohydrolase, broad substrate specificity, subgroup 3; Sly2001640; Belongs to the dGTPase family. Type 3 subfamily. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| dgt | surE-2 | D082_06310 | D082_31270 | dNTP triphosphohydrolase, broad substrate specificity, subgroup 3; Sly2001640; Belongs to the dGTPase family. Type 3 subfamily. | 5-nucleotidase SurE; Sly1005000. | 0.917 |
| guaA | apt | D082_10940 | D082_04420 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.862 |
| guaA | guaB-2 | D082_10940 | D082_32460 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | 0.999 |
| guaA | panC | D082_10940 | D082_11030 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase / Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. | 0.760 |
| guaA | purB | D082_10940 | D082_05960 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.967 |
| guaA | pyrF | D082_10940 | D082_24220 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.686 |
| guaA | pyrH | D082_10940 | D082_04050 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.833 |
| guaA | pyrR | D082_10940 | D082_07250 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.584 |
| guaA | surE | D082_10940 | D082_16750 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.961 |
| guaA | surE-2 | D082_10940 | D082_31270 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 5-nucleotidase SurE; Sly1005000. | 0.961 |
| guaB-2 | apt | D082_32460 | D082_04420 | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.530 |
| guaB-2 | guaA | D082_32460 | D082_10940 | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB-2 | panC | D082_32460 | D082_11030 | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | Pantoate--beta-alanine ligase / Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. | 0.723 |
| guaB-2 | purB | D082_32460 | D082_05960 | Inosine-5'-monophosphate dehydrogenase, catalytic domain; Sly1021250. | Adenylosuccinate lyase; Sly2001970; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.871 |