node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroA | dnaE-2 | gene:10499357 | gene:10500642 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.838 |
dnaB | dnaE | gene:10500020 | gene:10498105 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | 0.990 |
dnaB | dnaE-2 | gene:10500020 | gene:10500642 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.991 |
dnaB | dnaN | gene:10500020 | gene:10497730 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.433 |
dnaB | dnaX | gene:10500020 | gene:10498412 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA polymerase III subunit; ORF_ID:sll1360; gene:dnaX or dnaZ. | 0.848 |
dnaB | gyrA | gene:10500020 | gene:10497963 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA gyrase A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Belongs to the type II topoisomerase GyrA/ParC subunit family. | 0.986 |
dnaB | gyrA-2 | gene:10500020 | gene:10499881 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.988 |
dnaB | recA | gene:10500020 | gene:10500629 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | RecA gene product; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.947 |
dnaB | sll0544 | gene:10500020 | gene:10499993 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | ORF_ID:sll0544; unknown protein. | 0.442 |
dnaE | dnaB | gene:10498105 | gene:10500020 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | 0.990 |
dnaE | dnaE-2 | gene:10498105 | gene:10500642 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.999 |
dnaE | dnaN | gene:10498105 | gene:10497730 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.989 |
dnaE | dnaX | gene:10498105 | gene:10498412 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA polymerase III subunit; ORF_ID:sll1360; gene:dnaX or dnaZ. | 0.990 |
dnaE | dnaX-2 | gene:10498105 | gene:10499367 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA polymerase III subunit; ORF_ID:slr0446. | 0.986 |
dnaE | gyrA | gene:10498105 | gene:10497963 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA gyrase A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Belongs to the type II topoisomerase GyrA/ParC subunit family. | 0.915 |
dnaE | gyrA-2 | gene:10498105 | gene:10499881 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.926 |
dnaE | recA | gene:10498105 | gene:10500629 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | RecA gene product; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.790 |
dnaE | sll0544 | gene:10498105 | gene:10499993 | DNA polymerase III alpha subunit; ORF_ID:sll1572; gene:dnaE or polC. | ORF_ID:sll0544; unknown protein. | 0.987 |
dnaE-2 | aroA | gene:10500642 | gene:10499357 | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.838 |
dnaE-2 | dnaB | gene:10500642 | gene:10500020 | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | 0.991 |