wbbL_2 protein (Fusicatenibacter saccharivorans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

wbbL_2

dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol%2C alpha-3-L-rhamnosyltransferase. (330 aa)

Predicted Functional Partners:

algA

0.999

wcaJ_1

0.997

hyaD_1

0.997

cpsD_1

0.997

kfoC_3

0.994

CUO27113.1

0.991

arnB

0.982

gmd

0.972

CUO44819.1

0.958

ywqD

0.952

Your Current Organism:

Fusicatenibacter saccharivorans

NCBI taxonomy Id: 1150298
Other names: Clostridium sp. HT03-11, Clostridium sp. HT03-14, Clostridium sp. HT03-186, Clostridium sp. HT03-22, Clostridium sp. KO-38, Clostridium sp. TT-111, DSM 26062, F. saccharivorans, Fusicatenibacter saccharivorans Takada et al. 2013, JCM 18507, YIT 12554, strain HT03-11

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUO27113.1	algA	ERS852406_01611	ERS852406_02695	Uncharacterized protein conserved in bacteria.	Alginate biosynthesis protein AlgA.	0.922
CUO27113.1	cpsD_1	ERS852406_01611	ERS852406_01988	Uncharacterized protein conserved in bacteria.	Tyrosine-protein kinase CpsD.	0.587
CUO27113.1	gmd	ERS852406_01611	ERS852406_02697	Uncharacterized protein conserved in bacteria.	GDP-mannose 4%2C6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	0.464
CUO27113.1	hyaD_1	ERS852406_01611	ERS852406_01607	Uncharacterized protein conserved in bacteria.	Hyaluronan synthase.	0.966
CUO27113.1	kfoC_3	ERS852406_01611	ERS852406_01612	Uncharacterized protein conserved in bacteria.	Chondroitin polymerase.	0.993
CUO27113.1	wbbL_2	ERS852406_01611	ERS852406_01999	Uncharacterized protein conserved in bacteria.	dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol%2C alpha-3-L-rhamnosyltransferase.	0.991
CUO27113.1	wcaJ_1	ERS852406_01611	ERS852406_01605	Uncharacterized protein conserved in bacteria.	Putative colanic biosynthesis UDP-glucose lipid carrier transferase.	0.987
CUO44819.1	cpsD_1	ERS852406_01991	ERS852406_01988	Uncharacterised protein.	Tyrosine-protein kinase CpsD.	0.846
CUO44819.1	wbbL_2	ERS852406_01991	ERS852406_01999	Uncharacterised protein.	dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol%2C alpha-3-L-rhamnosyltransferase.	0.958
CUO44819.1	wcaJ_1	ERS852406_01991	ERS852406_01605	Uncharacterised protein.	Putative colanic biosynthesis UDP-glucose lipid carrier transferase.	0.850
CUO44819.1	ywqD	ERS852406_01991	ERS852406_01987	Uncharacterised protein.	Tyrosine-protein kinase YwqD.	0.694
algA	CUO27113.1	ERS852406_02695	ERS852406_01611	Alginate biosynthesis protein AlgA.	Uncharacterized protein conserved in bacteria.	0.922
algA	arnB	ERS852406_02695	ERS852406_01240	Alginate biosynthesis protein AlgA.	UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family.	0.569
algA	cpsD_1	ERS852406_02695	ERS852406_01988	Alginate biosynthesis protein AlgA.	Tyrosine-protein kinase CpsD.	0.423
algA	gmd	ERS852406_02695	ERS852406_02697	Alginate biosynthesis protein AlgA.	GDP-mannose 4%2C6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	0.988
algA	hyaD_1	ERS852406_02695	ERS852406_01607	Alginate biosynthesis protein AlgA.	Hyaluronan synthase.	0.812
algA	kfoC_3	ERS852406_02695	ERS852406_01612	Alginate biosynthesis protein AlgA.	Chondroitin polymerase.	0.922
algA	wbbL_2	ERS852406_02695	ERS852406_01999	Alginate biosynthesis protein AlgA.	dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol%2C alpha-3-L-rhamnosyltransferase.	0.999
algA	wcaJ_1	ERS852406_02695	ERS852406_01605	Alginate biosynthesis protein AlgA.	Putative colanic biosynthesis UDP-glucose lipid carrier transferase.	0.998
arnB	algA	ERS852406_01240	ERS852406_02695	UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family.	Alginate biosynthesis protein AlgA.	0.569

page 1 of 4

Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

8

PPI enrichment p-value:

3.49e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

5 of 5

2.58

4.14

1.23e-08

GO:0008652

Cellular amino acid biosynthetic process

6 of 98

1.37

1.67

6.86e-06

GO:0019752

Carboxylic acid metabolic process

7 of 329

0.91

0.81

0.00030

GO:0009058

Biosynthetic process

9 of 752

0.66

0.55

0.00040

GO:0044249

Cellular biosynthetic process

8 of 696

0.64

0.49

0.0028

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004834

Tryptophan synthase activity

2 of 2

2.58

1.05

0.0124

GO:0016829

Lyase activity

5 of 119

1.21

0.87

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:888

Aromatic amino acid biosynthesis, and ADC synthase

9 of 15

2.36

7.42

3.94e-17

CL:886

Phenylalanine, tyrosine and tryptophan biosynthesis, and Histidine biosynthetic process

10 of 33

2.06

6.26

3.94e-17

CL:891

Tryptophan biosynthesis

5 of 5

2.58

4.63

1.20e-09

CL:884

Biosynthesis of amino acids

11 of 94

1.65

4.06

3.06e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 25

2.09

5.37

1.14e-13

map01230

Biosynthesis of amino acids

10 of 131

1.47

2.86

8.46e-13

map01110

Biosynthesis of secondary metabolites

10 of 509

0.88

0.95

3.00e-07

map00260

Glycine, serine and threonine metabolism

3 of 45

1.41

0.95

0.0068

map01100

Metabolic pathways

10 of 1538

0.4

0.31

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

5 of 5

2.58

4.5

2.14e-09

KW-0028

Amino-acid biosynthesis

6 of 57

1.61

2.39

2.59e-07

KW-0456

Lyase

3 of 71

1.21

0.61

0.0398

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.58

0.91

0.0224

PF00425

Chorismate binding enzyme

2 of 2

2.58

0.91

0.0224

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011060

Ribulose-phosphate binding barrel

4 of 7

2.34

2.55

1.25e-05

IPR013785

Aldolase-type TIM barrel

5 of 48

1.6

1.7

8.60e-05

IPR019999

Anthranilate synthase component I-like

2 of 2

2.58

0.95

0.0189

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 2

2.58

0.95

0.0189

IPR005801

ADC synthase

2 of 2

2.58

0.95

0.0189

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About