node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCG07170.1 | CCG07475.1 | RSPPHO_00544 | RSPPHO_00849 | Anthranilate synthase, component II. | Prephenate dehydratase. | 0.468 |
CCG07170.1 | aroE | RSPPHO_00544 | RSPPHO_00924 | Anthranilate synthase, component II. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.802 |
CCG07170.1 | lexA | RSPPHO_00544 | RSPPHO_00541 | Anthranilate synthase, component II. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.602 |
CCG07170.1 | trpA | RSPPHO_00544 | RSPPHO_02672 | Anthranilate synthase, component II. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.977 |
CCG07170.1 | trpB-2 | RSPPHO_00544 | RSPPHO_02671 | Anthranilate synthase, component II. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.978 |
CCG07170.1 | trpC | RSPPHO_00544 | RSPPHO_00542 | Anthranilate synthase, component II. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
CCG07170.1 | trpD | RSPPHO_00544 | RSPPHO_00543 | Anthranilate synthase, component II. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
CCG07170.1 | trpE | RSPPHO_00544 | RSPPHO_01265 | Anthranilate synthase, component II. | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] | 0.999 |
CCG07170.1 | trpF | RSPPHO_00544 | RSPPHO_00303 | Anthranilate synthase, component II. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.998 |
CCG07475.1 | CCG07170.1 | RSPPHO_00849 | RSPPHO_00544 | Prephenate dehydratase. | Anthranilate synthase, component II. | 0.468 |
CCG07475.1 | aroE | RSPPHO_00849 | RSPPHO_00924 | Prephenate dehydratase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.556 |
CCG07475.1 | trpA | RSPPHO_00849 | RSPPHO_02672 | Prephenate dehydratase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.528 |
CCG07475.1 | trpB-2 | RSPPHO_00849 | RSPPHO_02671 | Prephenate dehydratase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.459 |
CCG07475.1 | trpC | RSPPHO_00849 | RSPPHO_00542 | Prephenate dehydratase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.570 |
CCG07475.1 | trpD | RSPPHO_00849 | RSPPHO_00543 | Prephenate dehydratase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.558 |
CCG07475.1 | trpE | RSPPHO_00849 | RSPPHO_01265 | Prephenate dehydratase. | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] | 0.528 |
CCG07475.1 | trpF | RSPPHO_00849 | RSPPHO_00303 | Prephenate dehydratase. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.510 |
aroE | CCG07170.1 | RSPPHO_00924 | RSPPHO_00544 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Anthranilate synthase, component II. | 0.802 |
aroE | CCG07475.1 | RSPPHO_00924 | RSPPHO_00849 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Prephenate dehydratase. | 0.556 |
aroE | trpA | RSPPHO_00924 | RSPPHO_02672 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.564 |