node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCG06882.1 | CCG07597.1 | RSPPHO_00256 | RSPPHO_00971 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.432 |
CCG06882.1 | CCG08930.1 | RSPPHO_00256 | RSPPHO_02304 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; Belongs to the GcvT family. | 0.713 |
CCG06882.1 | folD | RSPPHO_00256 | RSPPHO_00098 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.617 |
CCG06882.1 | glyA2 | RSPPHO_00256 | RSPPHO_02038 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
CCG07596.1 | CCG07597.1 | RSPPHO_00970 | RSPPHO_00971 | Putative uncharacterized protein. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.568 |
CCG07597.1 | CCG06882.1 | RSPPHO_00971 | RSPPHO_00256 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.432 |
CCG07597.1 | CCG07596.1 | RSPPHO_00971 | RSPPHO_00970 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Putative uncharacterized protein. | 0.568 |
CCG07597.1 | CCG07598.1 | RSPPHO_00971 | RSPPHO_00972 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Putative uncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.702 |
CCG07597.1 | CCG07599.1 | RSPPHO_00971 | RSPPHO_00973 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Putative uncharacterized protein. | 0.409 |
CCG07597.1 | CCG08647.1 | RSPPHO_00971 | RSPPHO_02021 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Peptidase M23B. | 0.720 |
CCG07597.1 | CCG08930.1 | RSPPHO_00971 | RSPPHO_02304 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.408 |
CCG07597.1 | CCG09055.1 | RSPPHO_00971 | RSPPHO_02429 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 5'-Nucleotidase; Belongs to the 5'-nucleotidase family. | 0.435 |
CCG07597.1 | folD | RSPPHO_00971 | RSPPHO_00098 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
CCG07597.1 | glyA2 | RSPPHO_00971 | RSPPHO_02038 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.442 |
CCG07597.1 | glyQ | RSPPHO_00971 | RSPPHO_01900 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycyl-tRNA synthetase alpha subunit. | 0.426 |
CCG07598.1 | CCG07597.1 | RSPPHO_00972 | RSPPHO_00971 | Putative uncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.702 |
CCG07598.1 | CCG07599.1 | RSPPHO_00972 | RSPPHO_00973 | Putative uncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | Putative uncharacterized protein. | 0.701 |
CCG07598.1 | CCG08647.1 | RSPPHO_00972 | RSPPHO_02021 | Putative uncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | Peptidase M23B. | 0.405 |
CCG07599.1 | CCG07597.1 | RSPPHO_00973 | RSPPHO_00971 | Putative uncharacterized protein. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.409 |
CCG07599.1 | CCG07598.1 | RSPPHO_00973 | RSPPHO_00972 | Putative uncharacterized protein. | Putative uncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.701 |