node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCG41725.1 | CCG41728.1 | PHAMO_290013 | PHAMO_290016 | Lauroyl/myristoyl acyltransferase. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.980 |
CCG41725.1 | kdsA | PHAMO_290013 | PHAMO_340140 | Lauroyl/myristoyl acyltransferase. | 2-dehydro-3-deoxyphosphooctonate aldolase (3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | 0.718 |
CCG41725.1 | kdsB | PHAMO_290013 | PHAMO_280197 | Lauroyl/myristoyl acyltransferase. | CTP:CMP-3-deoxy-D-manno-octulosonate transferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.773 |
CCG41725.1 | kdtA | PHAMO_290013 | PHAMO_290015 | Lauroyl/myristoyl acyltransferase. | 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.993 |
CCG41725.1 | lpxA | PHAMO_290013 | PHAMO_220006 | Lauroyl/myristoyl acyltransferase. | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.839 |
CCG41725.1 | lpxB | PHAMO_290013 | PHAMO_220004 | Lauroyl/myristoyl acyltransferase. | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.850 |
CCG41725.1 | lpxC | PHAMO_290013 | PHAMO_10060 | Lauroyl/myristoyl acyltransferase. | UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.838 |
CCG41725.1 | lpxD | PHAMO_290013 | PHAMO_220008 | Lauroyl/myristoyl acyltransferase. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.848 |
CCG41725.1 | lpxK | PHAMO_290013 | PHAMO_290014 | Lauroyl/myristoyl acyltransferase. | Tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.987 |
CCG41725.1 | msbA | PHAMO_290013 | PHAMO_290017 | Lauroyl/myristoyl acyltransferase. | Lipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.902 |
CCG41728.1 | CCG41725.1 | PHAMO_290016 | PHAMO_290013 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lauroyl/myristoyl acyltransferase. | 0.980 |
CCG41728.1 | kdsB | PHAMO_290016 | PHAMO_280197 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | CTP:CMP-3-deoxy-D-manno-octulosonate transferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.690 |
CCG41728.1 | kdtA | PHAMO_290016 | PHAMO_290015 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.990 |
CCG41728.1 | lpxA | PHAMO_290016 | PHAMO_220006 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.516 |
CCG41728.1 | lpxB | PHAMO_290016 | PHAMO_220004 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.461 |
CCG41728.1 | lpxC | PHAMO_290016 | PHAMO_10060 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.443 |
CCG41728.1 | lpxD | PHAMO_290016 | PHAMO_220008 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.603 |
CCG41728.1 | lpxK | PHAMO_290016 | PHAMO_290014 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.954 |
CCG41728.1 | msbA | PHAMO_290016 | PHAMO_290017 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.864 |
kdsA | CCG41725.1 | PHAMO_340140 | PHAMO_290013 | 2-dehydro-3-deoxyphosphooctonate aldolase (3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. | Lauroyl/myristoyl acyltransferase. | 0.718 |