node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCG42142.1 | hppA | PHAMO_340015 | PHAMO_340016 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.521 |
CCG42142.1 | nusB | PHAMO_340015 | PHAMO_340013 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Antitermination factor (L factor) (N utilization substance protein B); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.537 |
CCG42142.1 | ribB | PHAMO_340015 | PHAMO_340011 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.564 |
CCG42142.1 | ribD | PHAMO_340015 | PHAMO_340009 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Bifunctional: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.589 |
CCG42142.1 | ribH | PHAMO_340015 | PHAMO_340012 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.535 |
CCG42142.1 | thiL | PHAMO_340015 | PHAMO_340014 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.709 |
CCG43152.1 | hppA | PHAMO_580058 | PHAMO_340016 | Glutathione-regulated potassium-efflux system protein kefB; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.410 |
CCG43152.1 | ribB | PHAMO_580058 | PHAMO_340011 | Glutathione-regulated potassium-efflux system protein kefB; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.480 |
CCG43152.1 | ydbK | PHAMO_580058 | PHAMO_170063 | Glutathione-regulated potassium-efflux system protein kefB; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.505 |
fumA | hppA | PHAMO_270169 | PHAMO_340016 | Fumarase A (fumarate hydratase class I); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.440 |
fumA | ydbK | PHAMO_270169 | PHAMO_170063 | Fumarase A (fumarate hydratase class I); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.962 |
hppA | CCG42142.1 | PHAMO_340016 | PHAMO_340015 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.521 |
hppA | CCG43152.1 | PHAMO_340016 | PHAMO_580058 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Glutathione-regulated potassium-efflux system protein kefB; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.410 |
hppA | fumA | PHAMO_340016 | PHAMO_270169 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Fumarase A (fumarate hydratase class I); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.440 |
hppA | nusB | PHAMO_340016 | PHAMO_340013 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Antitermination factor (L factor) (N utilization substance protein B); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.454 |
hppA | ppa | PHAMO_340016 | PHAMO_320071 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Inorganic pyrophosphatase (Pyrophosphate phospho-hydrolase) (PPase); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.511 |
hppA | ribB | PHAMO_340016 | PHAMO_340011 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.509 |
hppA | ribD | PHAMO_340016 | PHAMO_340009 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Bifunctional: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.531 |
hppA | ribH | PHAMO_340016 | PHAMO_340012 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.446 |
hppA | thiL | PHAMO_340016 | PHAMO_340014 | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.536 |